muscle

abnormal muscle fiber morphology ( J:178228 )

• muscles exhibit very slight dilatation of sarcoplasmic triads compared to in control muscle

abnormal muscle contractility ( J:178228 )

• muscles exhibit increased susceptibility to loss of force generation in low or high potassium, mildly slowed kinetics for the rise and decay of force transients compared with control muscle

• recovery from loss of force is ouabain sensitive

• following glucose and insulin challenge, muscles exhibit loss of excitability and force and a 3-fold increased in compound muscle action potential compared with control muscles

muscle weakness ( J:178228 )

• hypokalemic-induced without myotonia

Mouse Models of Human Disease		OMIM ID	Ref(s)
Hypokalemic Periodic Paralysis, Type 2; HOKPP2		613345	J:178228