Mouse Genome Informatics
hm1
    Scn4atm1.1Cann/Scn4atm1.1Cann
involves: 129
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
muscle
• muscles exhibit very slight dilatation of sarcoplasmic triads compared to in control muscle
• muscles exhibit increased susceptibility to loss of force generation in low or high potassium, mildly slowed kinetics for the rise and decay of force transients compared with control muscle
• recovery from loss of force is ouabain sensitive
• following glucose and insulin challenge, muscles exhibit loss of excitability and force and a 3-fold increased in compound muscle action potential compared with control muscles
• hypokalemic-induced without myotonia

Mouse Models of Human Disease
OMIM IDRef(s)
Hypokalemic Periodic Paralysis, Type 2; HOKPP2 613345 J:178228


Mouse Genome Informatics
ht2
    Scn4atm1.1Cann/Scn4a+
involves: 129
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
muscle
• hypokalemic-induced without myotonia