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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Scn4atm1.1Cann
targeted mutation 1.1, Stephen C Cannon
MGI:5301528
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Scn4atm1.1Cann/Scn4atm1.1Cann involves: 129 MGI:5301550
ht2
Scn4atm1.1Cann/Scn4a+ involves: 129 MGI:5301551


Genotype
MGI:5301550
hm1
Allelic
Composition
Scn4atm1.1Cann/Scn4atm1.1Cann
Genetic
Background
involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scn4atm1.1Cann mutation (1 available); any Scn4a mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• muscles exhibit very slight dilatation of sarcoplasmic triads compared to in control muscle
• muscles exhibit increased susceptibility to loss of force generation in low or high potassium, mildly slowed kinetics for the rise and decay of force transients compared with control muscle
• recovery from loss of force is ouabain sensitive
• following glucose and insulin challenge, muscles exhibit loss of excitability and force and a 3-fold increased in compound muscle action potential compared with control muscles
• hypokalemic-induced without myotonia

Mouse Models of Human Disease
OMIM ID Ref(s)
Hypokalemic Periodic Paralysis, Type 2; HOKPP2 613345 J:178228




Genotype
MGI:5301551
ht2
Allelic
Composition
Scn4atm1.1Cann/Scn4a+
Genetic
Background
involves: 129
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Scn4atm1.1Cann mutation (1 available); any Scn4a mutation (38 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
muscle
• hypokalemic-induced without myotonia





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory