Phenotypes associated with this allele

• Allele Symbol: Scn4a^tm1.1Cann
• Allele Name: targeted mutation 1.1, Stephen C Cannon
• Allele ID: MGI:5301528
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Scn4a^tm1.1Cann/Scn4a^tm1.1Cann	involves: 129	MGI:5301550
ht2	Scn4a^tm1.1Cann/Scn4a^+	involves: 129	MGI:5301551

Genotype
MGI:5301550

hm1

• Allelic Composition: Scn4a^tm1.1Cann/Scn4a^tm1.1Cann
• Genetic Background: involves: 129

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

muscle

abnormal muscle fiber morphology ( J:178228 )

• muscles exhibit very slight dilatation of sarcoplasmic triads compared to in control muscle

abnormal muscle contractility ( J:178228 )

• muscles exhibit increased susceptibility to loss of force generation in low or high potassium, mildly slowed kinetics for the rise and decay of force transients compared with control muscle

• recovery from loss of force is ouabain sensitive

• following glucose and insulin challenge, muscles exhibit loss of excitability and force and a 3-fold increased in compound muscle action potential compared with control muscles

muscle weakness ( J:178228 )

• hypokalemic-induced without myotonia

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hypokalemic periodic paralysis		DOID:14452	OMIM:170400 OMIM:613345	J:178228

Genotype
MGI:5301551

ht2

• Allelic Composition: Scn4a^tm1.1Cann/Scn4a⁺
• Genetic Background: involves: 129

muscle

muscle weakness ( J:178228 )

• hypokalemic-induced without myotonia