Phenotypes associated with this allele
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map2k4tm1Ctr mutation
(0 available);
any
Map2k4 mutation
(32 available)
Map2k7tm1Rjd mutation
(0 available);
any
Map2k7 mutation
(19 available)
Tg(APPswe,PSEN1dE9)85Dbo mutation
(6 available)
Tg(Camk2a-cre/ERT2)2Gsc mutation
(1 available)
|
|
|
nervous system
|
• tamoxifen-treated mice develop fewer plaques than control mice expressing Tg(APPswe,PSEN1dE9)85Dbo
|
|
• tamoxifen-treated mice exhibit fewer dystrophic neurite clusters and few isolated neurites with residual bodies compared with control mice expressing Tg(APPswe,PSEN1dE9)85Dbo
|
homeostasis/metabolism
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map2k7tm1Rjd mutation
(0 available);
any
Map2k7 mutation
(19 available)
Tg(CAG-cre/Esr1*)5Amc mutation
(9 available)
|
|
|
nervous system
N |
• tamoxifen-treated neurons exhibit normal increases in neuron apoptosis following beta-amyloid 42 stimulation
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Map2k4tm1Ctr mutation
(0 available);
any
Map2k4 mutation
(32 available)
Map2k7tm1Rjd mutation
(0 available);
any
Map2k7 mutation
(19 available)
Tg(CAG-cre/Esr1*)5Amc mutation
(9 available)
|
|
|
cellular
|
• after beta-amyloid 42 stimulation, tamoxifen-treated neurons remain viable and do not exhibit increased caspase 3 activity unlike control neurons
|
nervous system
|
• after beta-amyloid 42 stimulation, tamoxifen-treated neurons remain viable and do not exhibit increased caspase 3 activity unlike control neurons
|