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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(tetO-Esr1)#Paf
transgene insertion, Priscilla A Furth
MGI:5296756
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Brca1tm2Cxd/Brca1tm2Cxd
Tg(MMTV-cre)4Mam/0
Tg(MMTV-rtTA)1Lach/0
Tg(tetO-Esr1)#Paf/0
Trp53tm1Brd/Trp53+ 		involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB MGI:5297135
cx2
 		Tg(MMTVtTA)1Mam/0
Tg(tetO-Esr1)#Paf/0 		involves: C57BL/6 * FVB/N * SJL MGI:5296757
cx3
 		Tg(MMTV-rtTA)1Lach/0
Tg(tetO-Esr1)#Paf/0 		involves: FVB/N MGI:5296806


Genotype
MGI:5297135
cn1
Allelic
Composition		 Brca1tm2Cxd/Brca1tm2Cxd
Tg(MMTV-cre)4Mam/0
Tg(MMTV-rtTA)1Lach/0
Tg(tetO-Esr1)#Paf/0
Trp53tm1Brd/Trp53+
Genetic
Background		 involves: 129S6/SvEvTac * 129S7/SvEvBrd * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Brca1tm2Cxd mutation (3 available); any Brca1 mutation (113 available)
Tg(MMTV-cre)4Mam mutation (1 available)
Tg(MMTV-rtTA)1Lach mutation (0 available)
Tg(tetO-Esr1)#Paf mutation (0 available)
Trp53tm1Brd mutation (5 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
mammary gland alveolar hyperplasia ( J:132088 )
• mutants develop hyperplastic alveolar nodules
increased mammary gland tumor incidence ( J:132088 )
• 100% of mutants develop invasive mammary cancer
• some cancers are Esr1-negative while others are Esr1-positive

neoplasm
increased mammary gland tumor incidence ( J:132088 )
• 100% of mutants develop invasive mammary cancer
• some cancers are Esr1-negative while others are Esr1-positive
preneoplasia ( J:132088 )
• mutants develop mammary gland preneoplasia
• some preneoplasia are Esr1-negative while others are Esr1-positive

integument
mammary gland alveolar hyperplasia ( J:132088 )
• mutants develop hyperplastic alveolar nodules
increased mammary gland tumor incidence ( J:132088 )
• 100% of mutants develop invasive mammary cancer
• some cancers are Esr1-negative while others are Esr1-positive

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
hereditary breast ovarian cancer syndrome DOID:5683 J:132088




Genotype
MGI:5296757
cx2
Allelic
Composition		 Tg(MMTVtTA)1Mam/0
Tg(tetO-Esr1)#Paf/0
Genetic
Background		 involves: C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(MMTVtTA)1Mam mutation (3 available)
Tg(tetO-Esr1)#Paf mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal seminal vesicle morphology ( J:78639 )
• when 14 week old males are removed from doxycycline administration for 50 days, seminal vesicles show a decrease in mass compared to controls

reproductive system
abnormal seminal vesicle morphology ( J:78639 )
• when 14 week old males are removed from doxycycline administration for 50 days, seminal vesicles show a decrease in mass compared to controls
decreased epididymis weight ( J:78639 )
• when 14 week old males are removed from doxycycline administration for 50 days, epididymis weight is decreased compared to controls
abnormal vas deferens morphology ( J:78639 )
• when 14 week old males are removed from doxycycline administration for 50 days, vas deferens weight is decreased compared to controls
short estrus ( J:78639 )
• females raised on doxycycline to block expression of Esr1 exhibit a decrease in the number of days in estrus when the doxycycline is removed and Esr1 is expressed, however overall cycle length is no different from controls
decreased litter size ( J:78639 )
• mutants without doxycycline (expressing Esr1) exhibit a 15% reduction in litter size compared to mutants receiving doxycycline




Genotype
MGI:5296806
cx3
Allelic
Composition		 Tg(MMTV-rtTA)1Lach/0
Tg(tetO-Esr1)#Paf/0
Genetic
Background		 involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal mammary gland morphology ( J:96383 )
• ovariectomized mice do not show ductal hyperplasia, ductal carcinoma in situ or other ductal abnormalities
• exposure to exogenous estrogen does not increase or change the prevalence of ductal abnormalities, proliferative disease or ductal carcinoma in situ
• neither hyperplasia nor ductal carcinoma in situ regress within a 2-week period following doxycycline treatment in 4 month old mutants
• mutants which were treated with doxycycline at 3 weeks of age to inhibit Esr1 expression exhibit normal mammary gland development
abnormal mammary gland epithelium morphology ( J:96383 )
• rates of mammary epithelial cell proliferation are increased compared to controls
abnormal mammary gland duct morphology ( J:96383 )
• at 4 months of age, mutants show abnormal mammary ductal structures, including lateral budding, dilated ducts, and abnormal branching
abnormal branching of the mammary ductal tree ( J:96383 )
• at 4 months of age, mutants show lateral budding and abnormal branching of mammary gland ducts
mammary gland duct hyperplasia ( J:96383 )
• 33% and 36% of mutants at 2 and 4 months of age, respectively, show ductal hyperplasia
abnormal mammary gland lobule morphology ( J:96383 )
• 52% of mutants at 4 months of age show lobular hyperplasia
mammary gland alveolar hyperplasia ( J:96383 )
• 12 month old mice display hyperplastic alveolar nodules with increased frequency of mitotic figures within the hyperplasias
increased mammary gland ductal carcinoma incidence ( J:96383 )
• 17% and 21% of mutants at 2 and 4 months of age, respectively, develop ductal carcinoma in situ

neoplasm
increased mammary gland ductal carcinoma incidence ( J:96383 )
• 17% and 21% of mutants at 2 and 4 months of age, respectively, develop ductal carcinoma in situ

integument
abnormal mammary gland morphology ( J:96383 )
• exposure to exogenous estrogen does not increase or change the prevalence of ductal abnormalities, proliferative disease or ductal carcinoma in situ
• neither hyperplasia nor ductal carcinoma in situ regress within a 2-week period following doxycycline treatment in 4 month old mutants
• ovariectomized mice do not show ductal hyperplasia, ductal carcinoma in situ or other ductal abnormalities
• mutants which were treated with doxycycline at 3 weeks of age to inhibit Esr1 expression exhibit normal mammary gland development
abnormal mammary gland epithelium morphology ( J:96383 )
• rates of mammary epithelial cell proliferation are increased compared to controls
abnormal mammary gland duct morphology ( J:96383 )
• at 4 months of age, mutants show abnormal mammary ductal structures, including lateral budding, dilated ducts, and abnormal branching
abnormal branching of the mammary ductal tree ( J:96383 )
• at 4 months of age, mutants show lateral budding and abnormal branching of mammary gland ducts
mammary gland duct hyperplasia ( J:96383 )
• 33% and 36% of mutants at 2 and 4 months of age, respectively, show ductal hyperplasia
abnormal mammary gland lobule morphology ( J:96383 )
• 52% of mutants at 4 months of age show lobular hyperplasia
mammary gland alveolar hyperplasia ( J:96383 )
• 12 month old mice display hyperplastic alveolar nodules with increased frequency of mitotic figures within the hyperplasias
increased mammary gland ductal carcinoma incidence ( J:96383 )
• 17% and 21% of mutants at 2 and 4 months of age, respectively, develop ductal carcinoma in situ

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
breast cancer DOID:1612 OMIM:114480
 J:96383




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/16/2024
MGI 6.23 		The Jackson Laboratory