Phenotypes associated with this allele

• Allele Symbol: Pbk^tm1Zgdo
• Allele Name: targeted mutation 1, Zigang Dong
• Allele ID: MGI:5293435
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pbk^tm1Zgdo/Pbk^tm1Zgdo	Not Specified	MGI:5294464

Genotype
MGI:5294464

hm1

• Allelic Composition: Pbk^tm1Zgdo/Pbk^tm1Zgdo
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

abnormal skin morphology ( J:176985 )

• UV-exposed mice exhibit increased deposition of the extracellular matrix unlike in similarly treated wild-type mice

abnormal epidermis stratum corneum morphology ( J:176985 )

• UV-exposed mice lose most of the horny layers of the epidermic compared with similarly treated wild-type mice

thick epidermis ( J:176985 )

• in UV-treated mice

skin fibrosis ( J:176985 )

• moderate in UV-treated mice

immune system

decreased interleukin-6 secretion ( J:176985 )

• LPS-stimulated mouse embryonic fibroblasts produce less IL6 compared with similarly treated wild-type cells

increased interleukin-6 secretion ( J:176985 )

• mouse embryonic fibroblasts exposed to solar UV radiation

increased tumor necrosis factor secretion ( J:176985 )

• mouse embryonic fibroblasts exposed to solar UV radiation