Analysis Tools
growth/size/body
|
• mice experiencing early death display cardiomegaly
|
mortality/aging
|
• about 3-4% of homozygotes experience spontaneous deaths as early as 4 months of age
|
reproductive system
 |
• dysplastic foci appearing at 9 months of age
|
|
|
• hypercellularity in the anterior lobes
• increased cell proliferation in the anterior lobe
|
|
|
• increased prostate weights as early as 2 months of age
|
|
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• hypercellularity in the ventral lobes
|
|
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• increased levels of apoptosis throughout the prostate
|
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• homozygous females are not impregnated by control males until 1-2 weeks after control females
|
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• homozygous males do not successfully impregnate control females until 2 weeks later than for control males
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infertility
(
J:138882
)
|
• 10-25% of homozygotes are fully infertile
|
behavior/neurological
| N |
• female nesting and suckling behavior is normal
|
|
• in some mice
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cardiovascular system
|
• mice experiencing early death display cardiomegaly
|
nervous system
|
• defective Purkinje cell layers in mice displaying a limb grasping phenotype
|
immune system
|
• increased red pulp area surrounding the germinal centers
|
|
• liver granulomas
|
liver/biliary system
|
• liver granulomas
|
respiratory system
|
• increased cell size and vascularity
|
endocrine/exocrine glands
|
|
• dysplastic foci appearing at 9 months of age
|
|
|
• hypercellularity in the anterior lobes
• increased cell proliferation in the anterior lobe
|
|
|
• increased prostate weights as early as 2 months of age
|
|
|
• hypercellularity in the ventral lobes
|
|
|
• increased levels of apoptosis throughout the prostate
|
hematopoietic system
|
• increased red pulp area surrounding the germinal centers
|
