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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Arhgap15tm1Ehi
targeted mutation 1, Emilio Hirsch
MGI:5142283
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Arhgap15tm1Ehi/Arhgap15tm1Ehi B6.129-Arhgap15tm1Ehi MGI:5142309


Genotype
MGI:5142309
hm1
Allelic
Composition
Arhgap15tm1Ehi/Arhgap15tm1Ehi
Genetic
Background
B6.129-Arhgap15tm1Ehi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arhgap15tm1Ehi mutation (0 available); any Arhgap15 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
N
• phagocyte differentiation is apparently normal
• monocyte/macrophage numbers reduced 43%
• bone marrow derived macrophage are more elongate in shape
• more membrane protrusions than in macrophage from controls
• monocyte/macrophage numbers reduced 43%
• increased migration toward chemoattractants
• small but significant increase in cell polarity
• increased phagocytosis of opsonized E. coli

immune system
N
• chemotactic responses of bone marrow derived macrophage are normal
• monocyte/macrophage numbers reduced 43%
• bone marrow derived macrophage are more elongate in shape
• more membrane protrusions than in macrophage from controls
• monocyte/macrophage numbers reduced 43%
• increased migration toward chemoattractants
• small but significant increase in cell polarity
• increased phagocytosis of opsonized E. coli
• better survival from caecal ligation and perforation sepsis





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/31/2020
MGI 6.15
The Jackson Laboratory