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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Vav1-ERG)#Jpim
transgene insertion, John E Pimanda
MGI:5141633
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Vav1-ERG)#Jpim/0 involves: C57BL/6 MGI:5548208


Genotype
MGI:5548208
tg1
Allelic
Composition
Tg(Vav1-ERG)#Jpim/0
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body

neoplasm
• all mice develop acute leukemia (J:174808)
• all other mice that do not have T-ALL develop myeloid leukemia, showing massive infiltration of leukemic blasts into the bone marrow, the spleen, and the liver, anemia, and thrombocytopenia (J:203438)
• leukemic cells are lineage negative and c-Kit+Sca-1-CD150+, characteristic of megakaryocyte-erythroid progenitors and gene expression and binding analysis show that these leukemias show a transcriptional program similar to human acute myeloid leukemia (J:203438)
• the Pim1 inhibitor SGI-1776 inhibits leukemia cell growth and induces apoptosis in these cells (J:203438)
• approximately 30% of leukemias are characterized as T-acute lymphoblastic leukemia (T-ALL) (J:174808)
• immunophenotype of the T-ALL blasts is cKit-CD3+CD8+CD4- (J:174808)
• about 30% of mice develop T-ALL (J:203438)

mortality/aging
• all mice that develop T-ALL die by 7 months of age with a median survival age of 20 weeks (J:174808)
• all mice that do not develop and die from T-ALL, die from myeloid leukemia by 5 months of age (J:203438)

hematopoietic system
• dense infiltration of thymus with lymphoblasts and almost complete disorganization of the tissue architecture

immune system
• dense infiltration of thymus with lymphoblasts and almost complete disorganization of the tissue architecture

endocrine/exocrine glands
• dense infiltration of thymus with lymphoblasts and almost complete disorganization of the tissue architecture

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
acute myeloid leukemia DOID:9119 OMIM:601626
J:203438





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last database update
10/19/2021
MGI 6.17
The Jackson Laboratory