All Phenotypes Epb41l3<tm1.1Bhat> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Epb41l3^tm1.1Bhat
targeted mutation 1.1, Manzoor A Bhat
MGI:5140704

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Epb41l3^tm1Bhat/Epb41l3^tm1.1Bhat Tmem163^{Tg(ACTB-cre)2Mrt}/0	involves: FVB/N	MGI:5140710

Allelic Composition	Epb41l3^tm1Bhat/Epb41l3^tm1.1Bhat Tmem163^{Tg(ACTB-cre)2Mrt}/0
Genetic Background	involves: FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Epb41l3^tm1.1Bhat mutation (0 available); any Epb41l3 mutation (46 available)
Epb41l3^tm1Bhat mutation (0 available); any Epb41l3 mutation (46 available)
Tmem163^{Tg(ACTB-cre)2Mrt} mutation (3 available); any Tmem163 mutation (35 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal paranode morphology ( J:173383 )

• accumulation of smooth endoplasmic reticulum in nodal-paranodal regions

abnormal paranodal axoglial junction morphology ( J:173383 )

• septate junction septa in sciatic nerves become more diffuse, most lacking electron dense granules at 1 month of age

• septa in sciatic nerves are diffuse and fuzzy at 3 months

• axolemma becomes detached from the myelin loops where septa are missing in the spinal cord

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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