Phenotypes associated with this allele

• Allele Symbol: Jam3^tm1.2Chav
• Allele Name: targeted mutation 1.2, Triantafyllos Chavakis
• Allele ID: MGI:5140161
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Jam3^tm1.2Chav/Jam3^tm1.2Chav	B6.129-Jam3^tm1.2Chav	MGI:5140205
hm2	Jam3^tm1.2Chav/Jam3^tm1.2Chav	involves: 129 * C57BL/6	MGI:5140204
cn3	Jam3^tm1.1Chav/Jam3^tm1.2Chav Tg(Cdh5-cre)7Mlia/?	involves: 129 * C57BL/6 * FVB/N	MGI:5140203

Genotype
MGI:5140205

hm1

• Allelic Composition: Jam3^tm1.2Chav/Jam3^tm1.2Chav
• Genetic Background: B6.129-Jam3^tm1.2Chav

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:173391 )

• born in slightly diminished numbers

preweaning lethality, incomplete penetrance ( J:173391 )

• experience considerable pre-weaning mortality

reproductive system

male infertility ( J:173391 )

♂ • surviving males are infertile

neoplasm

decreased metastatic potential ( J:173391 )

• significantly reduced B16 melanoma lung metastasis

Genotype
MGI:5140204

hm2

• Allelic Composition: Jam3^tm1.2Chav/Jam3^tm1.2Chav
• Genetic Background: involves: 129 * C57BL/6

mortality/aging

prenatal lethality, incomplete penetrance ( J:173391 )

• born in slightly diminished numbers

preweaning lethality, incomplete penetrance ( J:173391 )

• experience considerable pre-weaning mortality

reproductive system

male infertility ( J:173391 )

♂ • surviving males are infertile

Genotype
MGI:5140203

cn3

• Allelic Composition: Jam3^tm1.1Chav/Jam3^tm1.2Chav; Tg(Cdh5-cre)7Mlia/?
• Genetic Background: involves: 129 * C57BL/6 * FVB/N

neoplasm

decreased metastatic potential ( J:173391 )

• significantly reduced B16 melanoma lung metastasis