All Phenotypes Cd1d1<tm2Aben> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cd1d1^tm2Aben
targeted mutation 2, Albert Bendelac
MGI:5056289

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd1d1^tm2Aben/Cd1d1^tm2Aben	B6.129P2-Cd1d1^tm2Aben	MGI:5056351
hm2	Cd1d1^tm2Aben/Cd1d1^tm2Aben	involves: 129P2/OlaHsd * C57BL/6	MGI:5056352
cx3	Cd1d1^tm2Aben/Del(3Cd1d2-Cd1d1)1Crw	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6	MGI:5056353

Allelic Composition	Cd1d1^tm2Aben/Cd1d1^tm2Aben
Genetic Background	B6.129P2-Cd1d1^tm2Aben

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd1d1^tm2Aben mutation (1 available); any Cd1d1 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased NK T cell number ( J:174337 )

• mice exhibit a reduction of Valpha14 NKT cells in the thymus and peripheral tissues such as spleen and liver due to failure of positive selection compared with wild-type mice

abnormal antigen presentation ( J:174337 )

• thymocytes and peritoneal macrophages exhibit impaired antigen presentation of alphaGalCer compared with wild-type cells

hematopoietic system

decreased NK T cell number ( J:174337 )

• mice exhibit a reduction of Valpha14 NKT cells in the thymus and peripheral tissues such as spleen and liver due to failure of positive selection compared with wild-type mice

Allelic Composition	Cd1d1^tm2Aben/Cd1d1^tm2Aben
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd1d1^tm2Aben mutation (1 available); any Cd1d1 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased NK T cell number ( J:174337 )

• mice exhibit a reduction of Valpha14 NKT cells in the thymus and peripheral tissues such as spleen and liver due to failure of positive selection compared with wild-type mice

abnormal antigen presentation ( J:174337 )

• thymocytes and peritoneal macrophages exhibit impaired antigen presentation of alphaGalCer compared with wild-type cells

hematopoietic system

decreased NK T cell number ( J:174337 )

• mice exhibit a reduction of Valpha14 NKT cells in the thymus and peripheral tissues such as spleen and liver due to failure of positive selection compared with wild-type mice

Allelic Composition	Cd1d1^tm2Aben/Del(3Cd1d2-Cd1d1)1Crw
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd1d1^tm2Aben mutation (1 available); any Cd1d1 mutation (30 available)
Del(3Cd1d2-Cd1d1)1Crw mutation (0 available); any Del(3Cd1d2-Cd1d1)1Crw mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal antigen presentation ( J:174337 )

• peritoneal macrophages exhibit impaired antigen presentation of alphaGalCer compared with wild-type cells

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