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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(HTT*/EGFP)150Nn
transgene insertion 150, Nobuyuki Nukina
MGI:5052379
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(HTT*/EGFP)150Nn/0 involves: C57BL/6 * DBA/2 MGI:5052381


Genotype
MGI:5052381
tg1
Allelic
Composition
Tg(HTT*/EGFP)150Nn/0
Genetic
Background
involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• median survival is 32 weeks
• all die by 58 weeks of age

nervous system
• progression of neuropathology is less rapid compared to mice carrying Tg(HTT*/EGFP)190Nn
• dense EGFP positive aggregates are detected mostly in the cytoplasm at 35 weeks of age
• dense EGFP positive aggregates are detected mostly in the cytoplasm at 35 weeks of age
• dense EGFP positive aggregates are detected mostly in the cytoplasm at 35 weeks of age
• a few dense EGFP positive aggregates are detected in the nucleus but most are localized to the cytoplasm in the striatum, cortex and hippocampus at 35 weeks of age
• aggregates appear in both the nucleus and cytoplasm at 4 weeks of age but nuclear aggregates gradually lose EGFP fluorescence with age

behavior/neurological
• chorea-like movements
• show irregular, jerky involuntary head movements at about 16 weeks of age
• rare
• fine tremor with onset at about 9-11 weeks of age
• progressive development of an ataxic gait that is severe and interferes with walking by 30 weeks of age

Mouse Models of Human Disease
OMIM ID Ref(s)
Huntington Disease; HD 143100 J:174269





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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory