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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mitftm5.1Arnh
targeted mutation 5.1, Heinz Arnheiter
MGI:5050703
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mitftm5.1Arnh/Mitftm5.1Arnh involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6N MGI:5316607
ht2
 		Mitftm5.1Arnh/MitfMi-wh involves: 129S4/SvJae * 129S6/SvEvTac * C57BL * C57BL/6N * DBA MGI:5316609
cx3
 		Mitftm5.1Arnh/Mitftm5.1Arnh
Kittm1Alf/Kit+ 		involves: 129S2/SvPas * 129S4/SvJae * 129S6/SvEvTac * C57BL/6N MGI:5316641


Genotype
MGI:5316607
hm1
Allelic
Composition		 Mitftm5.1Arnh/Mitftm5.1Arnh
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEvTac * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitftm5.1Arnh mutation (0 available); any Mitf mutation (72 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
pigmentation phenotype ( J:182722 )
N
• normal pigmentation




Genotype
MGI:5316609
ht2
Allelic
Composition		 Mitftm5.1Arnh/MitfMi-wh
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEvTac * C57BL * C57BL/6N * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MitfMi-wh mutation (8 available); any Mitf mutation (72 available)
Mitftm5.1Arnh mutation (0 available); any Mitf mutation (72 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
integument
darkened coat color ( J:182722 )
• considerably darkened compared to heterozygous MitfMi-wh/Mitf+ mice

pigmentation
darkened coat color ( J:182722 )
• considerably darkened compared to heterozygous MitfMi-wh/Mitf+ mice




Genotype
MGI:5316641
cx3
Allelic
Composition		 Mitftm5.1Arnh/Mitftm5.1Arnh
Kittm1Alf/Kit+
Genetic
Background		 involves: 129S2/SvPas * 129S4/SvJae * 129S6/SvEvTac * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kittm1Alf mutation (1 available); any Kit mutation (179 available)
Mitftm5.1Arnh mutation (0 available); any Mitf mutation (72 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
belly spot ( J:182722 )
• slightly larger belly spots
abnormal melanocyte morphology ( J:182722 )
• more melanocytes around the eyes at E15.5 and at birth compared to controls involving Mitftm7.1Arnh
abnormal hair follicle melanocyte morphology ( J:182722 )
• more melanocytes in pigmented hair follicles found dorsally between the forelimbs compared to controls involving Mitftm7.1Arnh

integument
abnormal hair follicle melanocyte morphology ( J:182722 )
• more melanocytes in pigmented hair follicles found dorsally between the forelimbs compared to controls involving Mitftm7.1Arnh
belly spot ( J:182722 )
• slightly larger belly spots




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory