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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pax9tm1.1(Osr2)Jian
targeted mutation 1.1, Rulang Jiang
MGI:5013428
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pax9tm1.1(Osr2)Jian/Pax9tm1.1(Osr2)Jian involves: 129S1/Sv * C57BL/6J * FVB/N MGI:5013434
cx2
 		Osr2tm1Jian/Osr2tm1Jian
Pax9tm1.1(Osr2)Jian/Pax9+ 		involves: 129S1/Sv * C57BL/6J * FVB/N MGI:5013438


Genotype
MGI:5013434
hm1
Allelic
Composition		 Pax9tm1.1(Osr2)Jian/Pax9tm1.1(Osr2)Jian
Genetic
Background		 involves: 129S1/Sv * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax9tm1.1(Osr2)Jian mutation (0 available); any Pax9 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:173121 )
• mice die shortly after birth

craniofacial
abnormal mandible morphology ( J:173121 )
• mice exhibit defects in the alveolar bone in the mandible compared with wild-type mice
abnormal palatal shelf morphology ( J:173121 )
• at E13.5, the palatal shelves are broadened compared to in wild-type mice

skeleton
abnormal mandible morphology ( J:173121 )
• mice exhibit defects in the alveolar bone in the mandible compared with wild-type mice

limbs/digits/tail

digestive/alimentary system
abnormal palatal shelf morphology ( J:173121 )
• at E13.5, the palatal shelves are broadened compared to in wild-type mice

hearing/vestibular/ear

growth/size/body
arrest of tooth development ( J:173121 )
• at bud stage
abnormal palatal shelf morphology ( J:173121 )
• at E13.5, the palatal shelves are broadened compared to in wild-type mice
palatal shelves fail to meet at midline ( J:173121 )
• at E15.5
cleft secondary palate ( J:173121 )




Genotype
MGI:5013438
cx2
Allelic
Composition		 Osr2tm1Jian/Osr2tm1Jian
Pax9tm1.1(Osr2)Jian/Pax9+
Genetic
Background		 involves: 129S1/Sv * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Osr2tm1Jian mutation (1 available); any Osr2 mutation (17 available)
Pax9tm1.1(Osr2)Jian mutation (0 available); any Pax9 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
craniofacial
abnormal tooth development ( J:173121 )
• mice exhibit supernumerary tooth germs lingual to the maxillary molar compared with wild-type mice
• at E15.5 and E16.5, the oral epithelium lingual to the mandibular first molar tooth germs is thickened compared to in control mice
• however, the number of teeth in the mandible is normal
cleft secondary palate ( J:173121 )
• in all mice

digestive/alimentary system
cleft secondary palate ( J:173121 )
• in all mice

growth/size/body
abnormal tooth development ( J:173121 )
• mice exhibit supernumerary tooth germs lingual to the maxillary molar compared with wild-type mice
• at E15.5 and E16.5, the oral epithelium lingual to the mandibular first molar tooth germs is thickened compared to in control mice
• however, the number of teeth in the mandible is normal
cleft secondary palate ( J:173121 )
• in all mice

skeleton
abnormal tooth development ( J:173121 )
• mice exhibit supernumerary tooth germs lingual to the maxillary molar compared with wild-type mice
• at E15.5 and E16.5, the oral epithelium lingual to the mandibular first molar tooth germs is thickened compared to in control mice
• however, the number of teeth in the mandible is normal




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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory