Phenotypes associated with this allele

• Allele Symbol: Fgf21^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Pharmaceuticals
• Allele ID: MGI:5007140
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fgf21^tm1Lex/Fgf21^tm1Lex	involves: 129S5/SvEvBrd * C57BL/6N	MGI:5898008

Genotype
MGI:5898008

hm1

• Allelic Composition: Fgf21^tm1Lex/Fgf21^tm1Lex
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

abnormal brown adipose tissue physiology ( J:240649 )

• increased lipid content, impaired activity and whitening of brown adipocytes which is made worse by GW9508 treatment

abnormal brown adipose tissue thermogenesis ( J:240649 )

• impaired thermogenic activity

• impaired ability of GW9508, an activator of FFAR4, to induce thermogenic activation in brown adipose tissue

abnormal white adipose tissue physiology ( J:240649 )

• impaired browning of inguinal and epididymal white adipose tissue following GW9508 treatment

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:240649 )

• impaired ability of GW9508, an activator of FFAR4, to induce thermogenic activation in brown adipose tissue

• impaired browning of inguinal white adipose tissue following GW9508 treatment