Phenotypes associated with this allele

• Allele Symbol: Agpat4^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Pharmaceuticals
• Allele ID: MGI:5007015
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Agpat4^tm1Lex/Agpat4^tm1Lex	B6;129S5-Agpat4^tm1Lex/Mmucd	MGI:5828273

Genotype
MGI:5828273

hm1

• Allelic Composition: Agpat4^tm1Lex/Agpat4^tm1Lex
• Genetic Background: B6;129S5-Agpat4^tm1Lex/Mmucd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal phospholipid level ( J:231388 )

• brain extracts from homozygous mutant mice show a significant decrease in total cellular phosphatidylinositol (PI) content compared to controls

• the content of phosphatidylcholine (PC) was 39% lower in homozygous mouse brain extracts compared to controls

• the content of phosphatidylethanolamine (PE) was 32% lower in homozygous mouse brain extracts compared to controls

• significant enrichment of saturated fatty acids (SFAs) in phosphatidylinositol (PI) fraction

• significantly lower relative content of oleic acid (18:1n9) and eicosenoic acid (20:1n9) in phosphatidylinositol (PI) fraction

• significantly lower total MUFA species in phosphatidylinositol (PI) fraction

normal phenotype

no abnormal phenotype detected ( J:171883 )

• no notable phenotype was detected in a high-throughput screen of homozygous mice