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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Acp1tm1Lex
targeted mutation 1, Lexicon Pharmaceuticals
MGI:5007006
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Acp1tm1Lex/Acp1tm1Lex involves: 129S5/SvEvBrd * C57BL/6J MGI:5428928


Genotype
MGI:5428928
hm1
Allelic
Composition		 Acp1tm1Lex/Acp1tm1Lex
Genetic
Background		 involves: 129S5/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acp1tm1Lex mutation (1 available); any Acp1 mutation (12 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
increased fibroblast proliferation ( J:171883 )
• female mutant mice show an increased mean skin fibroblast proliferation rate

growth/size/body
decreased body size ( J:171883 )
• male homozygous mutant mice were notably smaller than their gender-matched control littermates

immune system
increased interleukin-6 secretion ( J:171883 )
• homozygous mutant mice exhibit an increased mean serum IL-6 response to LPS challenge when compared with that of controls




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory