Phenotypes associated with this allele

• Allele Symbol: Clmp^tm1Lex
• Allele Name: targeted mutation 1, Lexicon Pharmaceuticals
• Allele ID: MGI:5007002
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Clmp^tm1Lex/Clmp^tm1Lex	B6;129S5-Clmp^tm1Lex/Mmucd	MGI:5827982

Genotype
MGI:5827982

hm1

• Allelic Composition: Clmp^tm1Lex/Clmp^tm1Lex
• Genetic Background: B6;129S5-Clmp^tm1Lex/Mmucd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:171883 )

• this mutation resulted in reduced viability of the homozygous mutants

growth/size/body

decreased body size ( J:171883 )

• mutants were smaller than controls

cardiovascular system

increased systemic arterial systolic blood pressure ( J:171883 )

• notably increased mean systolic blood pressure

renal/urinary system

hydronephrosis ( J:171883 )

• both CAT-Scan analysis and necropsy revealed bilateral hydronephrosis in surviving homozygous mutant mice

behavior/neurological

abnormal behavior ( J:171883 )

• exhibited numerous neurological abnormalities

homeostasis/metabolism

abnormal blood homeostasis ( J:171883 )

• exhibited numerous blood chemistry abnormalities