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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Pnkd*A7V*A9V,-DsRed)671Ljp
transgene insertion 671, Louis J Ptacek
MGI:5006974
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Pnkdtm1Ljp/Pnkdtm1Ljp
Tg(Pnkd*A7V*A9V,-DsRed)671Ljp/0
involves: 129S1/Sv * 129X1/Sv * C57BL/6 * SJL MGI:5006976
tg2
Tg(Pnkd*A7V*A9V,-DsRed)671Ljp/0 B6.Cg-Tg(Pnkd*A7V*A9V,-DsRed)671Ljp MGI:5469978


Genotype
MGI:5006976
cx1
Allelic
Composition
Pnkdtm1Ljp/Pnkdtm1Ljp
Tg(Pnkd*A7V*A9V,-DsRed)671Ljp/0
Genetic
Background
involves: 129S1/Sv * 129X1/Sv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pnkdtm1Ljp mutation (1 available); any Pnkd mutation (49 available)
Tg(Pnkd*A7V*A9V,-DsRed)671Ljp mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
phenotype not analyzed




Genotype
MGI:5469978
tg2
Allelic
Composition
Tg(Pnkd*A7V*A9V,-DsRed)671Ljp/0
Genetic
Background
B6.Cg-Tg(Pnkd*A7V*A9V,-DsRed)671Ljp
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Pnkd*A7V*A9V,-DsRed)671Ljp mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• mice challenged with an injection of caffeine exhibit dyskinetic attacks about 10-15 minutes after treatment that persists for 2 hours compared to moderate hyperlocomotion during the first hour in wild-type controls
• mice challenged with an injection of ethanol exhibit dyskinetic attacks beginning 10 minutes after injection and lasting 2-4 hours, and show severe axial stiffness, with some abnormal movements of the limbs
• mice exhibit dyskinesia after stress such as prolonged handling, that includes oral-facial movements such as tongue protrusions and stereotypic movements such as repetitive sniffing and rearing in one location

homeostasis/metabolism
• while dopamine levels in the striatum are normal at rest, after injection of caffeine, mutants exhibit higher levels of the dopamine metabolite 3,4-dihydroxyphenylacetic acid (DOPAC), higher DOPAC/dopamine ratios, and higher levels of the terminal metabolite of dopamine, homovanillic acid, than wild-type mice
• however, mutants exhibit normal levels of serotonin and its metabolized product following stimulation with caffeine
• extracellular concentration of dopamine is less than 40% of that of controls under basal conditions, indicating lower striatal dopamine release at rest

nervous system
• mutants exhibit deficits in nigrostriatal neurotransmission characterized by low levels of dopamine release, enhanced dopamine reuptake, and increase of dopamine release in response to caffeine and ethanol
• mutants exhibit lower striatal dopamine release at rest, but an increase in percentage of striatal dopamine release in response to challenges with caffeine or stress

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
paroxysmal nonkinesigenic dyskinesia 1 DOID:0090049 OMIM:118800
J:192798





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory