Phenotypes associated with this allele

• Allele Symbol: Pnkd^tm1Ljp
• Allele Name: targeted mutation 1, Louis J Ptacek
• Allele ID: MGI:5006973
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pnkd^tm1Ljp/Pnkd^tm1Ljp	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5469981

Genotype
MGI:5469981

hm1

• Allelic Composition: Pnkd^tm1Ljp/Pnkd^tm1Ljp
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:192798 )

N • mice are fertile, with normal growth and no gross phenotypic abnormalities and do not exhibit dyskinesias following stress or caffeine or ethanol injection

homeostasis/metabolism

abnormal dopamine level ( J:192798 )

• while dopamine levels in the striatum are normal at rest, after injection of caffeine or ethanol, mutants exhibit lower levels of the dopamine metabolite 3,4-dihydroxyphenylacetic acid (DOPAC) and lower DOPAC/dopamine ratios than wild-type mice