Phenotypes associated with this allele

• Allele Symbol: Dazap1^tm1.2Pyen
• Allele Name: targeted mutation 1.2, Pauline Yen
• Allele ID: MGI:4950679
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dazap1^tm1.2Pyen/Dazap1^tm1.2Pyen	involves: 129S6/SvEvTac	MGI:4950688

Genotype
MGI:4950688

hm1

• Allelic Composition: Dazap1^tm1.2Pyen/Dazap1^tm1.2Pyen
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:171493 )

• males live no more than two months

• no females live beyond one month

lethality during fetal growth through weaning, incomplete penetrance ( J:171493 )

• reduced numbers of homozygotes found at 2 weeks of age

• about 1/3 of males and 1/10 of females live beyond 1 week of age

• some deaths occur in the first days of life

• homozygotes are under represented at E19.5

• homozygotes are present in normal numbers at E13.5/E14.5 although MEFs purified from them grow poorly

growth/size/body

postnatal growth retardation ( J:171493 )

reproductive system

abnormal spermatogenesis ( J:171493 )

♂ • begins but arrests with pachytene/diplotene spermatocytes at 25 days of age