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Allele Symbol Allele Name Allele ID |
Foxo3mommeR1 modifier of murine metastable epialleles, R1 MGI:4949204 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• oocytes are less likely to have a polar body on ovulation
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• apparent asynchronous development of the oocyte and follicle
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• at P3 some primordial follicles show an increase in the size of primary oocytes
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• oocytes are less likely to have a polar body on ovulation
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• apparent asynchronous development of the oocyte and follicle
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• at P3 some primordial follicles show an increase in the size of primary oocytes
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• at 18 weeks of age
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• at P30 compared to heterozygous controls
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• in some ovaries a disproportionate increase in oocyte size relative to the follicular cells is seen at P30
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• increase in the number of follicles at P30
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• marked decrease in the number of primary follicles at P60
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• increase in the number of secondary follicles at P30
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• at 18 weeks of age ovarian follicles are absent in 3 of 4 mice and the remaining mouse has a few degenerating primordial follicles
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• at P3 some primordial follicles show an increase in the size of primary oocytes
• at P14 most of the remaining primordial follicles contain an enlarged primary oocyte surrounded by spindle-shaped/squamous follicular cells
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• marked decrease in the number of primordial follicles at P60
• at 18 weeks of age 1 of 4 mice has a few degenerating primordial follicles
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• at 1 year of age occasional females have grossly enlarged ovaries
• at P30 compared to heterozygous controls
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• found in grossly enlarged ovaries at 1 year of age
• Background Sensitivity: teratomas are seen in about 1 in 6 mice of aged up to 8 months in mice on an FVB/NJ background but not in mice on an inbred C57BL/6J background
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• apparent asynchronous development of the oocyte and follicle
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• females lose fertility by about 8 weeks of age
• however, males display normal fertility
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• oocytes from superovulated females are less likely to have a polar body on the day of ovulation
• increased proportion of superovulated oocytes that are arrested at metaphase of meiosis I
• oocytes cultured overnight are more likely to fragment than those from superovulated heterozygous females
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• found in grossly enlarged ovaries at 1 year of age
• Background Sensitivity: teratomas are seen in about 1 in 6 mice of aged up to 8 months in mice on an FVB/NJ background but not in mice on an inbred C57BL/6J background
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• at P30 compared to heterozygous controls
• at 1 year of age occasional females have grossly enlarged ovaries
|
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• females lose fertility by about 8 weeks of age
• however, males display normal fertility
|
|
|
• at 18 weeks of age
|
|
|
• at P30 compared to heterozygous controls
|
|
|
• in some ovaries a disproportionate increase in oocyte size relative to the follicular cells is seen at P30
|
|
|
• increase in the number of follicles at P30
|
|
|
• marked decrease in the number of primary follicles at P60
|
|
|
• increase in the number of secondary follicles at P30
|
|
|
• at 18 weeks of age ovarian follicles are absent in 3 of 4 mice and the remaining mouse has a few degenerating primordial follicles
|
|
|
• at P3 some primordial follicles show an increase in the size of primary oocytes
• at P14 most of the remaining primordial follicles contain an enlarged primary oocyte surrounded by spindle-shaped/squamous follicular cells
|
|
|
• marked decrease in the number of primordial follicles at P60
• at 18 weeks of age 1 of 4 mice has a few degenerating primordial follicles
|
|
|
• at P30 compared to heterozygous controls
• at 1 year of age occasional females have grossly enlarged ovaries
|
|
|
• found in grossly enlarged ovaries at 1 year of age
• Background Sensitivity: teratomas are seen in about 1 in 6 mice of aged up to 8 months in mice on an FVB/NJ background but not in mice on an inbred C57BL/6J background
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• apparent asynchronous development of the oocyte and follicle
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| dermoid cyst of ovary | DOID:5117 |
OMIM:166950 |
J:170710 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• marked reduction in the number of primary follicles in some mice at 12 weeks of age
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• marked reduction in the number of primordial follicles in some mice at 12 weeks of age
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• in some mice at 12 weeks of age
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| N |
• unlike mice homozygous for Foxo3mommeR1 no ovarian teratomas are detected (in 7 mice)
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• marked reduction in the number of primary follicles in some mice at 12 weeks of age
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• marked reduction in the number of primordial follicles in some mice at 12 weeks of age
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• in some mice at 12 weeks of age
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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