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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Foxo3mommeR1
modifier of murine metastable epialleles, R1
MGI:4949204
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Foxo3mommeR1/Foxo3mommeR1 B6.FVB-Foxo3mommeR1 MGI:4949207
cx2
Foxo3mommeR1/Foxo3mommeR1
Tg(HBA1-Gfp)1Ew/Tg(HBA1-Gfp)1Ew
FVB/NJ-Foxo3mommeR1 Tg(HBA1-Gfp)1Ew MGI:4949205
cx3
Foxo3mommeR1/Foxo3tm1.1Rdp
Tg(HBA1-Gfp)1Ew/0
involves: 129S6/SvEvTac * C57BL/6 * FVB/NJ MGI:4949206


Genotype
MGI:4949207
hm1
Allelic
Composition
Foxo3mommeR1/Foxo3mommeR1
Genetic
Background
B6.FVB-Foxo3mommeR1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo3mommeR1 mutation (0 available); any Foxo3 mutation (21 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
N
• Background Sensitivity: unlike mice on an FVB/NJ background, no ovarian teratomas are detected on an inbred C57BL/6J background




Genotype
MGI:4949205
cx2
Allelic
Composition
Foxo3mommeR1/Foxo3mommeR1
Tg(HBA1-Gfp)1Ew/Tg(HBA1-Gfp)1Ew
Genetic
Background
FVB/NJ-Foxo3mommeR1 Tg(HBA1-Gfp)1Ew
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo3mommeR1 mutation (0 available); any Foxo3 mutation (21 available)
Tg(HBA1-Gfp)1Ew mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• at 18 weeks of age
• at P30 compared to heterozygous controls
• in some ovaries a disproportionate increase in oocyte size relative to the follicular cells is seen at P30
• increase in the number of follicles at P30
• marked decrease in the number of primary follicles at P60
• increase in the number of secondary follicles at P30
• at 18 weeks of age ovarian follicles are absent in 3 of 4 mice and the remaining mouse has a few degenerating primordial follicles
• at P3 some primordial follicles show an increase in the size of primary oocytes
• at P14 most of the remaining primordial follicles contain an enlarged primary oocyte surrounded by spindle-shaped/squamous follicular cells
• marked decrease in the number of primordial follicles at P60
• at 18 weeks of age 1 of 4 mice has a few degenerating primordial follicles
• at P30 compared to heterozygous controls
• at 1 year of age occasional females have grossly enlarged ovaries
• found in grossly enlarged ovaries at 1 year of age
• Background Sensitivity: teratomas are seen in about 1 in 6 mice of aged up to 8 months in mice on an FVB/NJ background but not in mice on an inbred C57BL/6J background
• apparent asynchronous development of the oocyte and follicle
• females lose fertility by about 8 weeks of age
• however, males display normal fertility
• oocytes are less likely to have a polar body on ovulation
• apparent asynchronous development of the oocyte and follicle
• at P3 some primordial follicles show an increase in the size of primary oocytes
• oocytes are less likely to have a polar body on ovulation
• increased proportion of superovulated oocytes that are arrested at metaphase of meiosis I
• oocytes cultured overnight are more likely to fragment than those from superovulated heterozygous females

neoplasm
• found in grossly enlarged ovaries at 1 year of age
• Background Sensitivity: teratomas are seen in about 1 in 6 mice of aged up to 8 months in mice on an FVB/NJ background but not in mice on an inbred C57BL/6J background

mortality/aging
• females lose fertility by about 8 weeks of age
• however, males display normal fertility

endocrine/exocrine glands
• at 18 weeks of age
• at P30 compared to heterozygous controls
• in some ovaries a disproportionate increase in oocyte size relative to the follicular cells is seen at P30
• increase in the number of follicles at P30
• marked decrease in the number of primary follicles at P60
• increase in the number of secondary follicles at P30
• at 18 weeks of age ovarian follicles are absent in 3 of 4 mice and the remaining mouse has a few degenerating primordial follicles
• at P3 some primordial follicles show an increase in the size of primary oocytes
• at P14 most of the remaining primordial follicles contain an enlarged primary oocyte surrounded by spindle-shaped/squamous follicular cells
• marked decrease in the number of primordial follicles at P60
• at 18 weeks of age 1 of 4 mice has a few degenerating primordial follicles
• at P30 compared to heterozygous controls
• at 1 year of age occasional females have grossly enlarged ovaries
• found in grossly enlarged ovaries at 1 year of age
• Background Sensitivity: teratomas are seen in about 1 in 6 mice of aged up to 8 months in mice on an FVB/NJ background but not in mice on an inbred C57BL/6J background
• apparent asynchronous development of the oocyte and follicle

Mouse Models of Human Disease
OMIM ID Ref(s)
Teratoma, Ovarian 166950 J:170710




Genotype
MGI:4949206
cx3
Allelic
Composition
Foxo3mommeR1/Foxo3tm1.1Rdp
Tg(HBA1-Gfp)1Ew/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxo3mommeR1 mutation (0 available); any Foxo3 mutation (21 available)
Foxo3tm1.1Rdp mutation (1 available); any Foxo3 mutation (21 available)
Tg(HBA1-Gfp)1Ew mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• marked reduction in the number of primary follicles in some mice at 12 weeks of age
• marked reduction in the number of primordial follicles in some mice at 12 weeks of age
• in some mice at 12 weeks of age

neoplasm
N
• unlike mice homozygous for Foxo3mommeR1 no ovarian teratomas are detected (in 7 mice)

endocrine/exocrine glands
• marked reduction in the number of primary follicles in some mice at 12 weeks of age
• marked reduction in the number of primordial follicles in some mice at 12 weeks of age
• in some mice at 12 weeks of age





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory