Mouse Genome Informatics
hm1
    Foxo3mommeR1/Foxo3mommeR1
B6.FVB-Foxo3mommeR1
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
tumorigenesis
N
• Background Sensitivity: unlike mice on an FVB/NJ background, no ovarian teratomas are detected on an inbred C57BL/6J background


Mouse Genome Informatics
cx2
    Foxo3mommeR1/Foxo3mommeR1
Tg(HBA1-Gfp)1Ew/Tg(HBA1-Gfp)1Ew

FVB/NJ-Foxo3mommeR1 Tg(HBA1-Gfp)1Ew
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• at 18 weeks of age
• at P30 compared to heterozygous controls
• in some ovaries a disproportionate increase in oocyte size relative to the follicular cells is seen at P30
• increase in the number of follicles at P30
• marked decrease in the number of primary follicles at P60
• increase in the number of secondary follicles at P30
• at 18 weeks of age ovarian follicles are absent in 3 of 4 mice and the remaining mouse has a few degenerating primordial follicles
• at P3 some primordial follicles show an increase in the size of primary oocytes
• at P14 most of the remaining primordial follicles contain an enlarged primary oocyte surrounded by spindle-shaped/squamous follicular cells
• marked decrease in the number of primordial follicles at P60
• at 18 weeks of age 1 of 4 mice has a few degenerating primordial follicles
• at P30 compared to heterozygous controls
• at 1 year of age occasional females have grossly enlarged ovaries
• apparent asynchronous development of the oocyte and follicle
• females lose fertility by about 8 weeks of age
• however, males display normal fertility
• oocytes are less likely to have a polar body on ovulation
• apparent asynchronous development of the oocyte and follicle
• at P3 some primordial follicles show an increase in the size of primary oocytes
• oocytes are less likely to have a polar body on ovulation
• increased proportion of superovulated oocytes that are arrested at metaphase of meiosis I
• oocytes cultured overnight are more likely to fragment than those from superovulated heterozygous females

tumorigenesis
• found in grossly enlarged ovaries at 1 year of age
• Background Sensitivity: teratomas are seen in about 1 in 6 mice of aged up to 8 months in mice on an FVB/NJ background but not in mice on an inbred C57BL/6J background

mortality/aging
• females lose fertility by about 8 weeks of age
• however, males display normal fertility

endocrine/exocrine glands
• at 18 weeks of age
• at P30 compared to heterozygous controls
• in some ovaries a disproportionate increase in oocyte size relative to the follicular cells is seen at P30
• increase in the number of follicles at P30
• marked decrease in the number of primary follicles at P60
• increase in the number of secondary follicles at P30
• at 18 weeks of age ovarian follicles are absent in 3 of 4 mice and the remaining mouse has a few degenerating primordial follicles
• at P3 some primordial follicles show an increase in the size of primary oocytes
• at P14 most of the remaining primordial follicles contain an enlarged primary oocyte surrounded by spindle-shaped/squamous follicular cells
• marked decrease in the number of primordial follicles at P60
• at 18 weeks of age 1 of 4 mice has a few degenerating primordial follicles
• at P30 compared to heterozygous controls
• at 1 year of age occasional females have grossly enlarged ovaries
• apparent asynchronous development of the oocyte and follicle

Mouse Models of Human Disease
OMIM IDRef(s)
Teratoma, Ovarian 166950 J:170710


Mouse Genome Informatics
cx3
    Foxo3mommeR1/Foxo3tm1.1Rdp
Tg(HBA1-Gfp)1Ew/0

involves: 129S6/SvEvTac * C57BL/6 * FVB/NJ
Key:
phenotype observed in females
phenotype observed in males
N normal phenotype
reproductive system
• marked reduction in the number of primary follicles in some mice at 12 weeks of age
• marked reduction in the number of primordial follicles in some mice at 12 weeks of age
• in some mice at 12 weeks of age

tumorigenesis
N
• unlike mice homozygous for Foxo3mommeR1 no ovarian teratomas are detected (in 7 mice)

endocrine/exocrine glands
• marked reduction in the number of primary follicles in some mice at 12 weeks of age
• marked reduction in the number of primordial follicles in some mice at 12 weeks of age
• in some mice at 12 weeks of age