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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Kcne3tm1Gwab
targeted mutation 1, Geoffrey W Abbott
MGI:4947550
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Kcne3tm1Gwab/Kcne3tm1Gwab B6.Cg-Kcne3tm1Gwab Tyrc-2J MGI:4947652
hm2
Kcne3tm1Gwab/Kcne3tm1Gwab involves: C57BL/6 MGI:5572818
cx3
Kcne2tm1Gwab/Kcne2tm1Gwab
Kcne3tm1Gwab/Kcne3tm1Gwab
involves: 129S4/SvJae * C57BL/6J MGI:4947654
cx4
Kcne2tm1Gwab/Kcne2+
Kcne3tm1Gwab/Kcne3tm1Gwab
involves: 129S4/SvJae * C57BL/6J MGI:4947655


Genotype
MGI:4947652
hm1
Allelic
Composition
Kcne3tm1Gwab/Kcne3tm1Gwab
Genetic
Background
B6.Cg-Kcne3tm1Gwab Tyrc-2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcne3tm1Gwab mutation (0 available); any Kcne3 mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
N
• mice exhibit normal stomach pH and response to histamine




Genotype
MGI:5572818
hm2
Allelic
Composition
Kcne3tm1Gwab/Kcne3tm1Gwab
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcne3tm1Gwab mutation (0 available); any Kcne3 mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cardiovascular system
• mice show an increase in frequency and duration of ventricular arrhythmogenesis during reperfusion immediately following transient ischemia, with all but one (which showed atrioventricular block) showing ventricular tachycardia
• pretreatment of mutants with spironolactone diminishes the differences in reperfusion arrhythmia incidence and halves the reperfusion ventricular tachycardia duration
• 9 month old females show prolonged QT(c) interval, indicating delayed ventricular repolarization
• treatment of 9 month old females with aldosterone receptor antagonist spironolactone results in no QT(c) prolongation
• prolonged T wave in 9 month old females

endocrine/exocrine glands
• mice show activated lymphocyte infiltration of the adrenal glands

homeostasis/metabolism
• serum aldosterone concentration is 2.3-fold higher than in wild-type mice
• decrease in free serum HDL
• increase in free and total serum LDL

immune system
• mice show activated lymphocyte infiltration of the adrenal glands




Genotype
MGI:4947654
cx3
Allelic
Composition
Kcne2tm1Gwab/Kcne2tm1Gwab
Kcne3tm1Gwab/Kcne3tm1Gwab
Genetic
Background
involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcne2tm1Gwab mutation (0 available); any Kcne2 mutation (8 available)
Kcne3tm1Gwab mutation (0 available); any Kcne3 mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• stomachs are 2-fold heavier than in wild-type mice
• compared with wild-type mice and Kcne2tm1Gwab homozygotes




Genotype
MGI:4947655
cx4
Allelic
Composition
Kcne2tm1Gwab/Kcne2+
Kcne3tm1Gwab/Kcne3tm1Gwab
Genetic
Background
involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcne2tm1Gwab mutation (0 available); any Kcne2 mutation (8 available)
Kcne3tm1Gwab mutation (0 available); any Kcne3 mutation (3 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system





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last database update
09/18/2018
MGI 6.12
The Jackson Laboratory