About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Calr3tm1Osb
targeted mutation 1, Research Institute for Microbial Diseases, Osaka University
MGI:4946941
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Calr3tm1Osb/Calr3tm1Osb involves: 129S2/SvPas * C57BL/6 MGI:4946943


Genotype
MGI:4946943
hm1
Allelic
Composition		 Calr3tm1Osb/Calr3tm1Osb
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Calr3tm1Osb mutation (4 available); any Calr3 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
impaired sperm migration in female genital tract ( J:170595 )
• sperm exhibit impaired migration into the oviduct compared with wild-type sperm
• however, sperm motility is normal

reproductive system
reproductive system phenotype ( J:170595 )
N
• female mice are fertile
impaired sperm migration in female genital tract ( J:170595 )
• sperm exhibit impaired migration into the oviduct compared with wild-type sperm
• however, sperm motility is normal
male infertility ( J:170595 )
• male mice are infertile
• however, transgenic expression recovers male fertility
impaired fertilization ( J:170595 )
• sperm exhibit reduced in vitro fertilization compared with wild-type sperm
impaired binding of sperm to zona pellucida ( J:170595 )
• sperm fail to bind to the zona pellucida compared with wild-type sperm




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory