About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Pink1tm1Hbu
targeted mutation 1, Hansruedi Bueler
MGI:4941901
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Pink1tm1Hbu/Pink1tm1Hbu involves: 129S7/SvEvBrd * C57BL/6 MGI:4941907


Genotype
MGI:4941907
hm1
Allelic
Composition
Pink1tm1Hbu/Pink1tm1Hbu
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pink1tm1Hbu mutation (0 available); any Pink1 mutation (8 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• in the striatum of LPS-treated mice (J:169471)
• in the striatum of LPS-treated mice (J:169471)
• in the striatum of LPS-treated mice (J:169471)
• in the striatum of LPS-treated mice (J:169471)
• in the striatum of LPS-treated mice (J:169471)
• in the striatum of LPS-treated mice (J:169471)

nervous system
• at 6 months, mice exhibit decreased dopamine in the striatum due to increased dopamine turnover compared with wild-type mice (J:169471)
• at 6 months, mice exhibit decreased dopamine in the striatum due to increased dopamine turnover compared with wild-type mice (J:169471)

cellular
• brain mitochondria exhibit reduced threshold for calcium-induced permeability transition pore opening compared with wild-type mitochondria (J:169471)
• brain mitochondria exhibit reduced threshold for calcium-induced permeability transition pore opening compared with wild-type mitochondria (J:169471)

homeostasis/metabolism
• at 6 months, mice exhibit decreased dopamine in the striatum due to increased dopamine turnover compared with wild-type mice (J:169471)
• at 6 months, mice exhibit decreased dopamine in the striatum due to increased dopamine turnover compared with wild-type mice (J:169471)

Mouse Models of Human Disease
OMIM ID Ref(s)
Parkinson Disease 6, Autosomal Recessive Early-Onset; PARK6 605909 J:169471





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
02/02/2016
MGI 6.02
The Jackson Laboratory