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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Pink1tm1Hbu
targeted mutation 1, Hansruedi Bueler
MGI:4941901
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Pink1tm1Hbu/Pink1tm1Hbu involves: 129S7/SvEvBrd * C57BL/6 MGI:4941907


Genotype
MGI:4941907
hm1
Allelic
Composition
Pink1tm1Hbu/Pink1tm1Hbu
Genetic
Background
involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pink1tm1Hbu mutation (0 available); any Pink1 mutation (24 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• in the striatum of LPS-treated mice
• in the striatum of LPS-treated mice
• in the striatum of LPS-treated mice

nervous system
• at 6 months, mice exhibit decreased dopamine in the striatum due to increased dopamine turnover compared with wild-type mice

cellular
• brain mitochondria exhibit reduced threshold for calcium-induced permeability transition pore opening compared with wild-type mitochondria

homeostasis/metabolism
• at 6 months, mice exhibit decreased dopamine in the striatum due to increased dopamine turnover compared with wild-type mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
autosomal recessive early-onset Parkinson disease 6 DOID:0060369 OMIM:605909
J:169471





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/15/2017
MGI 6.10
The Jackson Laboratory