Mouse Genome Informatics
hm1
    Pink1tm1Hbu/Pink1tm1Hbu
involves: 129S7/SvEvBrd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• in the striatum of LPS-treated mice
• in the striatum of LPS-treated mice
• in the striatum of LPS-treated mice

nervous system
• at 6 months, mice exhibit decreased dopamine in the striatum due to increased dopamine turnover compared with wild-type mice

cellular
• brain mitochondria exhibit reduced threshold for calcium-induced permeability transition pore opening compared with wild-type mitochondria

homeostasis/metabolism
• at 6 months, mice exhibit decreased dopamine in the striatum due to increased dopamine turnover compared with wild-type mice