About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Sgms1tm1Kenw
targeted mutation 1, Ken Watanabe
MGI:4939657
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Sgms1tm1Kenw/Sgms1tm1Kenw involves: 129S2/SvPas * C57BL/6 MGI:4939664


Genotype
MGI:4939664
hm1
Allelic
Composition
Sgms1tm1Kenw/Sgms1tm1Kenw
Genetic
Background
involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sgms1tm1Kenw mutation (2 available); any Sgms1 mutation (204 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 50% of mice die by 10 weeks of age
• however, lethality is partially rescued by anti-oxidant treatment

homeostasis/metabolism
• mice exhibit decreased insulin secretion compared with wild-type mice
• however, insulin secretion is partially rescued by anti-oxidant treatment
• after fasting
• in a glucose tolerance test, mice exhibit impaired glucose uptake compared with wild-type mice
• however, glucose tolerance is partially rescued by anti-oxidant treatment

endocrine/exocrine glands
• islet cells exhibit mitochondrial abnormalities with increased reactive oxygen species generation compared with wild-type cells
• however, no abnormal islet cell death is observed
• mice exhibit decreased insulin secretion compared with wild-type mice
• however, insulin secretion is partially rescued by anti-oxidant treatment

growth/size/body

adipose tissue

cellular
• islet cells exhibit mitochondrial abnormalities with increased reactive oxygen species generation compared with wild-type cells





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
03/30/2021
MGI 6.16
The Jackson Laboratory