Phenotypes associated with this allele

• Allele Symbol: Sgms1^tm1Kenw
• Allele Name: targeted mutation 1, Ken Watanabe
• Allele ID: MGI:4939657
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sgms1^tm1Kenw/Sgms1^tm1Kenw	involves: 129S2/SvPas * C57BL/6	MGI:4939664

Genotype
MGI:4939664

hm1

• Allelic Composition: Sgms1^tm1Kenw/Sgms1^tm1Kenw
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:168726 )

• 50% of mice die by 10 weeks of age

• however, lethality is partially rescued by anti-oxidant treatment

homeostasis/metabolism

decreased insulin secretion ( J:168726 )

• mice exhibit decreased insulin secretion compared with wild-type mice

• however, insulin secretion is partially rescued by anti-oxidant treatment

hyperglycemia ( J:168726 )

• after fasting

decreased circulating insulin level ( J:168726 )

impaired glucose tolerance ( J:168726 )

• in a glucose tolerance test, mice exhibit impaired glucose uptake compared with wild-type mice

• however, glucose tolerance is partially rescued by anti-oxidant treatment

increased insulin sensitivity ( J:168726 )

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:168726 )

• islet cells exhibit mitochondrial abnormalities with increased reactive oxygen species generation compared with wild-type cells

• however, no abnormal islet cell death is observed

decreased insulin secretion ( J:168726 )

• mice exhibit decreased insulin secretion compared with wild-type mice

• however, insulin secretion is partially rescued by anti-oxidant treatment

growth/size/body

decreased body weight ( J:168726 )

adipose tissue

decreased white adipose tissue amount ( J:168726 )

cellular

oxidative stress ( J:168726 )

• islet cells exhibit mitochondrial abnormalities with increased reactive oxygen species generation compared with wild-type cells