Mouse Genome Informatics
tg1
    Tg(Igh-Maf)68Staka/0
C57BL/6-Tg(Igh-Maf)68Staka
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
immune system
• in the spleen and bone marrow
• infiltration of plasma-like cells partially destroys normal tissue architecture
• 2- to 5-fold
• after 60 weeks, mice exhibit hyperglobulinemia compared with wild-type mice
• in aged mice
• in aged mice

tumorigenesis
• 28% of mice develop lymphoma (mean age of diagnosis is 80 weeks)
• lymphoma cells exhibit autonomous proliferation when transplanted into nude mice

renal/urinary system
• after 60 weeks, mice exhibit renal tubular casts and tubular obstructions compared with wild-type mice

hematopoietic system
• in the spleen and bone marrow
• infiltration of plasma-like cells partially destroys normal tissue architecture
• 2- to 5-fold
• after 60 weeks, mice exhibit hyperglobulinemia compared with wild-type mice
• in aged mice
• in aged mice

Mouse Models of Human Disease
OMIM IDRef(s)
Myeloma, Multiple 254500 J:168074