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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Igh-Maf)68Staka
transgene insertion 68, Satoru Takahashi
MGI:4939022
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Igh-Maf)68Staka/0 C57BL/6-Tg(Igh-Maf)68Staka MGI:4939026


Genotype
MGI:4939026
tg1
Allelic
Composition
Tg(Igh-Maf)68Staka/0
Genetic
Background
C57BL/6-Tg(Igh-Maf)68Staka
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• in the spleen and bone marrow
• infiltration of plasma-like cells partially destroys normal tissue architecture
• 2- to 5-fold
• after 60 weeks, mice exhibit hyperglobulinemia compared with wild-type mice
• in aged mice
• in aged mice

neoplasm
• 28% of mice develop lymphoma (mean age of diagnosis is 80 weeks)
• lymphoma cells exhibit autonomous proliferation when transplanted into nude mice

renal/urinary system
• after 60 weeks, mice exhibit renal tubular casts and tubular obstructions compared with wild-type mice

hematopoietic system
• in the spleen and bone marrow
• infiltration of plasma-like cells partially destroys normal tissue architecture
• 2- to 5-fold
• after 60 weeks, mice exhibit hyperglobulinemia compared with wild-type mice
• in aged mice
• in aged mice

Mouse Models of Human Disease
OMIM ID Ref(s)
Myeloma, Multiple 254500 J:168074





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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory