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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Hbs1ltm1a(KOMP)Wtsi
targeted mutation 1a, Wellcome Trust Sanger Institute
MGI:4887599
Summary 2 genotypes


Genotype
MGI:5700912
hm1
Allelic
Composition
Hbs1ltm1a(KOMP)Wtsi/Hbs1ltm1a(KOMP)Wtsi
Genetic
Background
C57BL/6N-Hbs1ltm1a(KOMP)Wtsi/Wtsi
Cell Lines EPD0693_2_A02
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hbs1ltm1a(KOMP)Wtsi mutation (3 available); any Hbs1l mutation (33 available)
Data Sources
phenotype observed in females
phenotype observed in males
N normal phenotype
adipose tissue

craniofacial
• 86% of females exhibit depressed nasal bones compared to 43% of males
• 86% of females exhibit shortened nasal bones compared to 14% of males
• depressed zygomatic bones
• mice exhibit abnormal facial structure that is more prevalent in females than males
• dental asymmetry

growth/size/body
• mice exhibit abnormal facial structure that is more prevalent in females than males
• dental asymmetry
• mice weigh less at various ages

hematopoietic system
IMPC - WTSI

homeostasis/metabolism

immune system

limbs/digits/tail

pigmentation
• atypical retinal pigmentation

reproductive system
IMPC - WTSI (J:211773)
MGI (J:272028)

skeleton
• dental asymmetry
• 86% of females exhibit depressed nasal bones compared to 43% of males
• 86% of females exhibit shortened nasal bones compared to 14% of males
• depressed zygomatic bones
• vertebral defects such as transitional vertebrae and abnormal shape
IMPC - WTSI (J:211773)

vision/eye
IMPC - WTSI
• atypical retinal pigmentation




Genotype
MGI:6718851
hm2
Allelic
Composition
Hbs1ltm1a(KOMP)Wtsi/Hbs1ltm1a(KOMP)Wtsi
Genetic
Background
C57BL/6NTac-Hbs1ltm1a(KOMP)Wtsi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hbs1ltm1a(KOMP)Wtsi mutation (3 available); any Hbs1l mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• no mice are recovered at E6.5

reproductive system
• no mice are recovered at E6.5





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory