All Phenotypes Pld2<tm1.1Gdp> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pld2^tm1.1Gdp
targeted mutation 1.1, Gilbert Di Paolo
MGI:4880012

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pld2^tm1.1Gdp/Pld2^tm1.1Gdp	involves: 129/SvJ * C57BL/6	MGI:5468550
hm2	Pld2^tm1.1Gdp/Pld2^tm1.1Gdp	involves: 129X1/SvJ * C57BL/6	MGI:4880013
cx3	Pld2^tm1.1Gdp/Pld2^tm1.1Gdp Tg(APPSWE)2576Kha/0	involves: 129X1/SvJ * C57BL/6 * SJL	MGI:4880014
cx4	Pld2^tm1.1Gdp/Pld2⁺ Tg(APPSWE)2576Kha/0	involves: 129X1/SvJ * C57BL/6 * SJL	MGI:4880015

Allelic Composition	Pld2^tm1.1Gdp/Pld2^tm1.1Gdp
Genetic Background	involves: 129/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pld2^tm1.1Gdp mutation (1 available); any Pld2 mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

neoplasm ( J:193451 )

N	• implanted B16F10 mouse melanoma or mouse Lewis lung carcinoma cells exhibit normal growth, vascularization and metastasis

Allelic Composition	Pld2^tm1.1Gdp/Pld2^tm1.1Gdp
Genetic Background	involves: 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pld2^tm1.1Gdp mutation (1 available); any Pld2 mutation (48 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal lipid level ( J:166741 )

• mice exhibit altered levels of specific phosphatidic acids compared to in wild-type mice

abnormal response/metabolism to endogenous compounds ( J:166741 )

• Abeta42 oligomers fail to suppress long term potential unlike in wild-type mice

Allelic Composition	Pld2^tm1.1Gdp/Pld2^tm1.1Gdp Tg(APPSWE)2576Kha/0
Genetic Background	involves: 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pld2^tm1.1Gdp mutation (1 available); any Pld2 mutation (48 available)
Tg(APPSWE)2576Kha mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:166741 )

N	• mice exhibit normal spatial working memory unlike Tg(APPSWE)2576Kha mice

enhanced contextual conditioning behavior ( J:166741 )

• compared to Tg(APPSWE)2576Kha mice

homeostasis/metabolism

abnormal lipid level ( J:166741 )

• mice exhibit altered levels of specific phosphatidic acids compared to in wild-type mice

nervous system

abnormal synapse morphology ( J:166741 )

• mice exhibit synaptic protection compared to in Tg(APPSWE)2576Kha mice

Allelic Composition	Pld2^tm1.1Gdp/Pld2⁺ Tg(APPSWE)2576Kha/0
Genetic Background	involves: 129X1/SvJ * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pld2^tm1.1Gdp mutation (1 available); any Pld2 mutation (48 available)
Tg(APPSWE)2576Kha mutation (5 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:166741 )

N	• mice exhibit normal spatial working memory unlike Tg(APPSWE)2576Kha mice

enhanced contextual conditioning behavior ( J:166741 )

• compared to Tg(APPSWE)2576Kha mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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