Phenotypes associated with this allele

• Allele Symbol: Itm2b^tm3.1Ldad
• Allele Name: targeted mutation 3.1, Luciano D'Adamio
• Allele ID: MGI:4867871
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Itm2b^tm3.1Ldad/Itm2b^tm3.1Ldad	B6.129-Itm2b^tm3.1Ldad	MGI:4867886

Genotype
MGI:4867886

hm1

• Allelic Composition: Itm2b^tm3.1Ldad/Itm2b^tm3.1Ldad
• Genetic Background: B6.129-Itm2b^tm3.1Ldad

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired contextual conditioning behavior ( J:166696 )

impaired long-term object recognition memory ( J:166696 )

• mice spend the same time exploring a novel and familiar object introduced 24 hours prior unlike wild-type mice

impaired spatial working memory ( J:166696 )

• mice exhibit impaired spatial working memory compared with wild-type mice

nervous system

nervous system phenotype ( J:166696 )

N • mice do not exhibit familial British dementia-related neuropathy

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cerebral amyloid angiopathy		DOID:9246		J:166696