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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
B3gnt5tm1Big
targeted mutation 1, Darell D Bigner
MGI:4867401
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
B3gnt5tm1Big/B3gnt5tm1Big C57BL/6-B3gnt5tm1Big MGI:4867405
ht2
B3gnt5tm1Big/B3gnt5+ C57BL/6-B3gnt5tm1Big MGI:4867406


Genotype
MGI:4867405
hm1
Allelic
Composition
B3gnt5tm1Big/B3gnt5tm1Big
Genetic
Background
C57BL/6-B3gnt5tm1Big
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B3gnt5tm1Big mutation (0 available); any B3gnt5 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• some die immediately after birth
• an increasing number of mutant mice die between 5-15 months of age
• some dams die during delivery

reproductive system
• in homozygous x homozygous matings

immune system
• decrease in the number of CD19+ B cells in the spleen
• the limits between the germinal center and red pulp are blurred
• in some splenic nodules the germinal center architecture is disturbed or the germinal center is missing

growth/size/body
• age related obesity is seen in some males at about 5 months of age

hematopoietic system
• decrease in the number of CD19+ B cells in the spleen
• the limits between the germinal center and red pulp are blurred
• in some splenic nodules the germinal center architecture is disturbed or the germinal center is missing




Genotype
MGI:4867406
ht2
Allelic
Composition
B3gnt5tm1Big/B3gnt5+
Genetic
Background
C57BL/6-B3gnt5tm1Big
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B3gnt5tm1Big mutation (0 available); any B3gnt5 mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• some dams die during delivery

reproductive system
• in heterozygous x heterozygous matings
• lower pregnancy rate than expected in heterozygous x heterozygous matings
• some heterozygous pairs lose fertility after the first mating

growth/size/body
• age related obesity is seen in some males at about 5 months of age





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/13/2017
MGI 6.11
The Jackson Laboratory