Phenotypes associated with this allele

• Allele Symbol: Sct^tm1.1Bkcc
• Allele Name: targeted mutation 1.1, Billy K C Chow
• Allele ID: MGI:4847670
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sct^tm1.1Bkcc/Sct^tm1.1Bkcc	B6.Cg-Sct^tm1.1Bkcc	MGI:4847903

Genotype
MGI:4847903

hm1

• Allelic Composition: Sct^tm1.1Bkcc/Sct^tm1.1Bkcc
• Genetic Background: B6.Cg-Sct^tm1.1Bkcc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal circulating antidiuretic hormone level ( J:166370 )

• salt-loading for 5 days or ANGII treatment fails to increase serum vasopressin concentration unlike similarly treated wild-type mice

abnormal response/metabolism to endogenous compounds ( J:166370 )

• SCT-treated mice do not exhibit an increase in water consumption unlike in wild-type mice

• mice treated with a single dose of ANGII by intracerebroventricular injection fail to exhibit an increase in water consumption compared with similarly treated wild-type mice

• mice treated with a continuous dose of ANGII by intracerebroventricular injection exhibit a reduced increase in water consumption compared with similarly treated wild-type mice

• salt-loading for 5 days fails to increase serum vasopressin concentration unlike similarly treated wild-type mice

• however, increased water intake is observed when SCT is centrally injected as a single dose or continuously

behavior/neurological

abnormal drinking behavior ( J:166370 )

• SCT-treated mice do not exhibit an increase in water consumption unlike in wild-type mice

• mice treated with a single dose of ANGII by intracerebroventricular injection fail to exhibit an increase in water consumption compared with similarly treated wild-type mice

• mice treated with a continuous dose of ANGII by intracerebroventricular injection exhibit a reduced increase in water consumption compared with similarly treated wild-type mice

• however, increased water intake is observed when SCT is centrally injected as a single dose or continuously