Phenotypes associated with this allele

• Allele Symbol: P2ry13^tm1Loma
• Allele Name: targeted mutation 1, Laurent O Martinez
• Allele ID: MGI:4839758
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	P2ry13^tm1Loma/P2ry13^tm1Loma	B6.129-P2ry13^tm1Loma	MGI:4839910

Genotype
MGI:4839910

hm1

• Allelic Composition: P2ry13^tm1Loma/P2ry13^tm1Loma
• Genetic Background: B6.129-P2ry13^tm1Loma

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

liver/biliary system

decreased liver cholesterol level ( J:166205 )

abnormal bile secretion ( J:166205 )

• mice exhibit reduced bile flow, biliary cholesterol secretion, and bile acid secretion compared with wild-type mice

• cangrelor treatment fails to increase of cholesterol, bile acid, and phospholipids biliary secretion unlike in wild-type mice

abnormal hepatocyte physiology ( J:166205 )

• reduced staining of vesicular structures positive for fluorescent DyLight549 suggests impaired receptor-mediated HDL uptake compared to in similarly treated wild-type cells

• hepatocytes treated with a P2ry13 agonist, cangrelor, fail to exhibit an increase in labeled HDL uptake compared with similarly treated wild-type cells

homeostasis/metabolism

abnormal cellular cholesterol metabolism ( J:166205 )

• mice exhibit reduced overall macrophage-to-feces reverse cholesterol transport compared with wild-type mice

decreased liver cholesterol level ( J:166205 )

decreased physiological sensitivity to xenobiotic ( J:166205 )

• hepatocytes treated with a P2ry13 agonist, cangrelor, fail to exhibit an increase in labeled HDL uptake compared with similarly treated wild-type cells

• cangrelor treatment fails to increase of cholesterol, bile acid, and phospholipids biliary secretion unlike in wild-type mice

cellular

abnormal cellular cholesterol metabolism ( J:166205 )

• mice exhibit reduced overall macrophage-to-feces reverse cholesterol transport compared with wild-type mice