Analysis Tools
mortality/aging
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• fewer than expected mice are found at E15.5
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• most mice die shortly after birth with only 2 of 326 mice surviving longer
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immune system
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• lymphatic vessels contain blood cells unlike in wild-type mice
• lymphatic vessels exhibit a dilated, tortuous, and rugged appearance unlike in wild-type mice
• at E14.5 and E17.5, anastomotic sites of blood and lymphatic vessels are observed unlike in wild-type mice
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• mice exhibit defects in lymphatic drainage compared with wild-type mice
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cardiovascular system
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• at E14.5 and E17.5, anastomotic sites of blood and lymphatic vessels are observed unlike in wild-type mice
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hemorrhage
(
J:165898
)
|
• at E12.5 to E13.5, mice exhibit cutaneous hemorrhage unlike wild-type mice
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hematopoietic system
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• platelets from chimeric mice generated using fetal liver transplantation fail to exhibit rhodocytin-induced activation unlike wild-type cells
• however, platelet adhesion and spreading on a surface coated with collage, fibrinogen, laminin, and vWF are normal
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• platelets from chimeric mice generated using fetal liver transplantation exhibit impaired stable thrombus formation under flow conditions and in vivo compared with wild-type cells
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homeostasis/metabolism
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• platelets from chimeric mice generated using fetal liver transplantation fail to exhibit rhodocytin-induced activation unlike wild-type cells
• however, platelet adhesion and spreading on a surface coated with collage, fibrinogen, laminin, and vWF are normal
|
|
• platelets from chimeric mice generated using fetal liver transplantation exhibit impaired stable thrombus formation under flow conditions and in vivo compared with wild-type cells
|
skin edema
(
J:165898
)
|
• in the back skin
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integument
skin edema
(
J:165898
)
|
• in the back skin
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