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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Ivns1abptm1Htno
targeted mutation 1, Masahiko Hatano
MGI:4820513
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Ivns1abptm1Htno/Ivns1abptm1Htno involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:4820514


Genotype
MGI:4820514
hm1
Allelic
Composition
Ivns1abptm1Htno/Ivns1abptm1Htno
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ivns1abptm1Htno mutation (0 available); any Ivns1abp mutation (20 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 90% of doxorubicin-treated mice die within 4 weeks unlike 60% of similarly treated wild-type mice
• fewer than expected mice are produced (no time of death or observation given)

homeostasis/metabolism
• in doxorubicin-treated mice
• in doxorubicin-treated mice
• 90% of doxorubicin-treated mice die within 4 weeks unlike 60% of similarly treated wild-type mice
• mice exhibit doxorubicin-induced cardiotoxicity with massive bilateral pleural effusion and ascites indicative of congestive heart failure, poor movement of left anterior ventricular wall, decreased left ventricular ejection fraction, and increased apoptotic cardiomyocytes compared with similarly treated wild-type mice

cardiovascular system
• in doxorubicin-treated mice
• in doxorubicin-treated mice

cellular
• in doxorubicin-treated mice
• mouse embryonic fibroblasts (MEF) treated with cytochalasin D exhibit apoptosis unlike similarly treated wild-type cells
• doxorubicin-treated MEFs exhibit increased apoptosis compared with similarly treated wild-type cells

muscle
• in doxorubicin-treated mice
• in doxorubicin-treated mice

respiratory system
• in doxorubicin-treated mice





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/16/2024
MGI 6.23
The Jackson Laboratory