Mouse Genome Informatics
tg1
    Tg(Umod*C147W)958Lura/0
involves: FVB
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
renal/urinary system
• kidney cells exhibit endoplasmic reticulum hyperplasia, protein inclusions, and cell necrosis unlike in Tg(Umod)416Lura mice
• at 12 weeks, mice exhibit sparse tubular atrophy unlike Tg(Umod)416Lura mice
• from 24 weeks, mice exhibit progressive tubulo-interstitial damage with increasing fibrosis, tubular cysts in the cortico-medullary area, and damaged tubules with cells containing vesicular structures and dense material compared with Tg(Umod)416Lura mice
• from 24 weeks, mice exhibit tracts of increased thickness or multilayered tubular basement membrane or gaps of the tubular basement membrane unlike in Tg(Umod)416Lura mice
• at 12 weeks, mice exhibit sparse tubular atrophy unlike Tg(Umod)416Lura mice
• mild to moderate at 12 weeks of age
• kidney tubular cells exhibit cell necrosis unlike in Tg(Umod)416Lura mice
• at 12 weeks, some dilated tubules are filled with proteins casts
• tubular cysts in the cortico-medullary area after 24 weeks
• mice fail to concentrate urine when subjected to water deprivation unlike Tg(Umod)416Lura mice
• mice exhibit increased kidney cell proliferation unlike Tg(Umod)416Lura mice
• mice exhibit progressive interstitial inflammation with increased cell proliferation unlike Tg(Umod)416Lura mice
• mice exhibit increased numbers of interstitial macrophage between 12 and 24 weeks, particularly in the renal medulla, unlike Tg(Umod)416Lura mice

homeostasis/metabolism

behavior/neurological

immune system
• mice exhibit progressive interstitial inflammation with increased cell proliferation unlike Tg(Umod)416Lura mice
• mice exhibit increased numbers of interstitial macrophage between 12 and 24 weeks, particularly in the renal medulla, unlike Tg(Umod)416Lura mice

cellular
• mice exhibit increased kidney cell proliferation unlike Tg(Umod)416Lura mice