About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Umod*C147W)958Lura
transgene insertion 958, Luca Rampoldi
MGI:4819096
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Umod*C147W)958Lura/0 involves: FVB MGI:4819114


Genotype
MGI:4819114
tg1
Allelic
Composition
Tg(Umod*C147W)958Lura/0
Genetic
Background
involves: FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
renal/urinary system
• kidney cells exhibit endoplasmic reticulum hyperplasia, protein inclusions, and cell necrosis unlike in Tg(Umod)416Lura mice
• at 12 weeks, mice exhibit sparse tubular atrophy unlike Tg(Umod)416Lura mice
• from 24 weeks, mice exhibit progressive tubulo-interstitial damage with increasing fibrosis, tubular cysts in the cortico-medullary area, and damaged tubules with cells containing vesicular structures and dense material compared with Tg(Umod)416Lura mice
• from 24 weeks, mice exhibit tracts of increased thickness or multilayered tubular basement membrane or gaps of the tubular basement membrane unlike in Tg(Umod)416Lura mice
• at 12 weeks, mice exhibit sparse tubular atrophy unlike Tg(Umod)416Lura mice
• mild to moderate at 12 weeks of age
• kidney tubular cells exhibit cell necrosis unlike in Tg(Umod)416Lura mice
• at 12 weeks, some dilated tubules are filled with proteins casts
• tubular cysts in the cortico-medullary area after 24 weeks
• mice exhibit increased kidney cell proliferation unlike Tg(Umod)416Lura mice
• mice exhibit progressive interstitial inflammation with increased cell proliferation unlike Tg(Umod)416Lura mice
• mice exhibit increased numbers of interstitial macrophage between 12 and 24 weeks, particularly in the renal medulla, unlike Tg(Umod)416Lura mice
• mice fail to concentrate urine when subjected to water deprivation unlike Tg(Umod)416Lura mice

homeostasis/metabolism

behavior/neurological

immune system
• mice exhibit progressive interstitial inflammation with increased cell proliferation unlike Tg(Umod)416Lura mice
• mice exhibit increased numbers of interstitial macrophage between 12 and 24 weeks, particularly in the renal medulla, unlike Tg(Umod)416Lura mice

cellular
• mice exhibit increased kidney cell proliferation unlike Tg(Umod)416Lura mice





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/22/2016
MGI 6.06
The Jackson Laboratory