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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Prnp-APP*)1Hmor
transgene insertion 1, Hiroshi Mori
MGI:4818971
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(Prnp-APP*)1Hmor/0 B6.Cg-Tg(Prnp-APP*)1Hmor MGI:4818990


Genotype
MGI:4818990
tg1
Allelic
Composition
Tg(Prnp-APP*)1Hmor/0
Genetic
Background
B6.Cg-Tg(Prnp-APP*)1Hmor
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• no amyloid plaques are observed unlike in Tg(APPSWE)2576Kha mice
• at 12 months
• at 18 months
• mice exhibit an intraneuronal accumulation of APP oligomers in the cerebral cortex, hippocampus, and cerebellum unlike in Tg(APPSWE)2576Kha or Tg(Prnp-APP)#Hmor mice
• at 24 months, fewer neurons are found in the hippocampal CA3 region compared to in wild-type mice

behavior/neurological
• mice exhibit increased escape latency in a Morris water maze compared with Tg(Prnp-APP)#Hmor and wild-type mice

immune system
• at 12 months

hematopoietic system
• at 12 months

Mouse Models of Human Disease
OMIM ID Ref(s)
Alzheimer Disease; AD 104300 J:159623





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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory