Phenotypes associated with this allele

• Allele Symbol: Ar^tm2Ska
• Allele Name: targeted mutation 2, Shigeaki Kato
• Allele ID: MGI:4461236
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ar^tm2Ska/Y Gli1^tm3(cre/ERT2)Alj/Gli1^+	involves: 129S6/SvEvTac * C57BL/6 * CBA	MGI:4461249
cn2	Ar^tm2Ska/Y Shh^tm2(cre/ERT2)Cjt/Shh^+	involves: 129S6/SvEvTac * C57BL/6 * CBA	MGI:4461253
cn3	Ar^tm2Ska/Y Tg(KRT5-cre)1Tak/0	involves: C3H * C57BL/6 * CBA	MGI:4461252

Genotype
MGI:4461249

cn1

• Allelic Composition: Ar^tm2Ska/Y; Gli1^{tm3(cre/ERT2)Alj}/Gli1⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal external male genitalia morphology ( J:148515 )

♂ • tamoxifen-treated mice exhibit hypoplastic external genitalia compared with wild-type mice

♂ • external genitalis of tamoxifen-treated mice are feminized

abnormal foreskin morphology ( J:148515 )

♂ • underdeveloped in tamoxifen-treated mice

abnormal reproductive system development ( J:148515 )

♂ • prospective corporal bodies from tamoxifen-treated mice fail to differentiate or bilaterally segment in the mesenchyme unlike in wild-type mice

♂ • however, development of internal reproductive organs are normally in tamoxifen-treated mice

renal/urinary system

abnormal foreskin morphology ( J:148515 )

♂ • underdeveloped in tamoxifen-treated mice

Genotype
MGI:4461253

cn2

• Allelic Composition: Ar^tm2Ska/Y; Shh^{tm2(cre/ERT2)Cjt}/Shh⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * CBA

reproductive system

reproductive system phenotype ( J:148515 )

♂N • tamoxifen-treated mice exhibit normal masculinization

Genotype
MGI:4461252

cn3

• Allelic Composition: Ar^tm2Ska/Y; Tg(KRT5-cre)1Tak/0
• Genetic Background: involves: C3H * C57BL/6 * CBA

reproductive system

reproductive system phenotype ( J:148515 )

♂N • mice exhibit normal masculinization