Phenotypes associated with this allele

• Allele Symbol: Fastk^tm1.1Andp
• Allele Name: targeted mutation 1, Paul Anderson
• Allele ID: MGI:4461026
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fastk^tm1.1Andp/Fastk^tm1.1Andp	B6.129S6-Fastk^tm1.1Andp	MGI:4461027

Genotype
MGI:4461027

hm1

• Allelic Composition: Fastk^tm1.1Andp/Fastk^tm1.1Andp
• Genetic Background: B6.129S6-Fastk^tm1.1Andp

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

decreased neutrophil cell number ( J:160443 )

• absence of neutrophils in bronchoalveolar lavage from mice exposed to house dust mite extract

• reduced pulmonary neutrophil accumulation in response to LPS induced pulmonay inflammation

abnormal neutrophil physiology ( J:160443 )

• neutrophils move significantly faster in a chemotactic chamber

immune system

decreased neutrophil cell number ( J:160443 )

• absence of neutrophils in bronchoalveolar lavage from mice exposed to house dust mite extract

• reduced pulmonary neutrophil accumulation in response to LPS induced pulmonay inflammation

abnormal neutrophil physiology ( J:160443 )

• neutrophils move significantly faster in a chemotactic chamber

abnormal chemokine secretion ( J:160443 )

• bronchoalveolar lavage fluid from LPS-treated mice contains significantly less Mip-2/CXCL2 and KC/CXCL1

decreased interleukin-23 secretion ( J:160443 )

• bronchoalveolar lavage fluid from LPS-treated mice contains significantly less IL23

decreased interleukin-6 secretion ( J:160443 )

• bronchoalveolar lavage fluid from LPS-treated mice contains significantly less IL6

decreased tumor necrosis factor secretion ( J:160443 )

• bronchoalveolar lavage fluid from LPS-treated mice contains significantly less TNF-a

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:160443 )

• resistant to LPS induced pulmonary inflammation compared with wild-type controls