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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Fastktm1.1Andp
targeted mutation 1, Paul Anderson
MGI:4461026
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Fastktm1.1Andp/Fastktm1.1Andp B6.129S6-Fastktm1.1Andp MGI:4461027


Genotype
MGI:4461027
hm1
Allelic
Composition
Fastktm1.1Andp/Fastktm1.1Andp
Genetic
Background
B6.129S6-Fastktm1.1Andp
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fastktm1.1Andp mutation (1 available); any Fastk mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• absence of neutrophils in bronchoalveolar lavage from mice exposed to house dust mite extract
• reduced pulmonary neutrophil accumulation in response to LPS induced pulmonay inflammation
• neutrophils move significantly faster in a chemotactic chamber

immune system
• absence of neutrophils in bronchoalveolar lavage from mice exposed to house dust mite extract
• reduced pulmonary neutrophil accumulation in response to LPS induced pulmonay inflammation
• neutrophils move significantly faster in a chemotactic chamber
• bronchoalveolar lavage fluid from LPS-treated mice contains significantly less Mip-2/CXCL2 and KC/CXCL1
• bronchoalveolar lavage fluid from LPS-treated mice contains significantly less IL23
• bronchoalveolar lavage fluid from LPS-treated mice contains significantly less IL6
• bronchoalveolar lavage fluid from LPS-treated mice contains significantly less TNF-a

homeostasis/metabolism
• resistant to LPS induced pulmonary inflammation compared with wild-type controls





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory