Phenotypes associated with this allele

• Allele Symbol: Igf1^tm2.1Nros
• Allele Name: targeted mutation 1.1, Nadia Rosenthal
• Allele ID: MGI:4459505
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Igf1^tm2.1Nros/Igf1^tm2.1Nros	involves: BALB/c * C57BL/6	MGI:4459506
ht2	Igf1^tm2.1Nros/Igf1^+	involves: BALB/c * C57BL/6	MGI:4459507

Genotype
MGI:4459506

hm1

• Allelic Composition: Igf1^tm2.1Nros/Igf1^tm2.1Nros
• Genetic Background: involves: BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:159167 )

• upon delivery mice fail to start breathing they become cyanotic and die within minutes

growth/size/body

decreased birth weight ( J:159167 )

• only 59% of wild-type weight at birth

respiratory system

abnormal lung morphology ( J:159167 )

• isolated lungs sink when immersed in water, whereas the lungs of wild-type mice float

primary atelectasis ( J:159167 )

respiratory failure ( J:159167 )

• immediately after birth

Genotype
MGI:4459507

ht2

• Allelic Composition: Igf1^tm2.1Nros/Igf1⁺
• Genetic Background: involves: BALB/c * C57BL/6

growth/size/body

decreased birth weight ( J:159167 )

• only 92% of wild-type weight at birth