Phenotypes associated with this allele

• Allele Symbol: Slitrk5^tm2Vlcg
• Allele Name: targeted mutation 2, Velocigene
• Allele ID: MGI:4459459
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slitrk5^tm2Vlcg/Slitrk5^tm2Vlcg	involves: 129S/Sv * C57BL/6	MGI:4459460
ht2	Slitrk5^tm2Vlcg/Slitrk5^+	involves: 129S/Sv * C57BL/6	MGI:4459461

Genotype
MGI:4459460

hm1

• Allelic Composition: Slitrk5^tm2Vlcg/Slitrk5^tm2Vlcg
• Genetic Background: involves: 129S/Sv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

hemorrhage ( J:160616 )

• over time excessive grooming results in ulcerations with hemorrhage

behavior/neurological

behavior/neurological phenotype ( J:160616 )

N • no difference in gross motor skills and no impairment in motor learning

enhanced behavioral response to xenobiotic ( J:160616 )

• chronic administration fluoxetine leads to a significant reduction in the duration of grooming

increased anxiety-related response ( J:160616 )

• mice show a lower percentage of time spent in the center compartment and a lower number of entries into the center compartment in the open-field test

• reduced time spent in open arms in the elevated-plus-maze test

• increase in marble-burying behavior

increased grooming behavior ( J:160616 )

• a significant increase in the duration of grooming events compared to wild-type

• chronic administration fluoxetine leads to a significant reduction in the duration of grooming

nervous system

abnormal striatum morphology ( J:160616 )

• volume of striatum is significantly reduced compared to wild-type mice

abnormal medium spiny neuron morphology ( J:160616 )

• significant decrease in dendritic complexity of striatal neurons

• a decrease in dendritic arbor complexity at distances greater or equal to 50 um from the soma

abnormal synaptic transmission ( J:160616 )

• a significantly reduced population spike amplitude as a measure of defects in corticostriatal neurotransmission

integument

alopecia ( J:160616 )

• at three months of age mice show facial hair loss from excessive grooming

skin lesions ( J:160616 )

• at three months of age mice develop severe ulcerations from excessive grooming

Genotype
MGI:4459461

ht2

• Allelic Composition: Slitrk5^tm2Vlcg/Slitrk5⁺
• Genetic Background: involves: 129S/Sv * C57BL/6

behavior/neurological

increased grooming behavior ( J:160616 )

• excessive grooming

integument

skin lesions ( J:160616 )

• at 10-12 months of age develop from excessive grooming