Analysis Tools
mortality/aging
|
• most pups die after birth
|
nervous system
|
• fewer cells expressing neuronal marker TBR1 (superficial neurons) are found near the bottom of the cortex than expected
• fewer cells expressing neuronal marker BRN2 (deep layer neurons)are found at the top of the cortex than expected and more cells are found near the bottom of the cortex
|
|
• enlarged lateral ventricle in 4 out 18 animals
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digestive/alimentary system
cleft palate
(
J:215665
)
|
• cleft palate is observed in 94% (17 or 18) mice
|
growth/size/body
cleft palate
(
J:215665
)
|
• cleft palate is observed in 94% (17 or 18) mice
|
limbs/digits/tail
polydactyly
(
J:215665
)
|
• polydactyly is observed in 94% (17 or 18) mice
|
craniofacial
cleft palate
(
J:215665
)
|
• cleft palate is observed in 94% (17 or 18) mice
|
cellular
|
• decrease in length of primary cilia from E15.5 choroid plexus
|
|
• fewer cells expressing neuronal marker TBR1 (superficial neurons) are found near the bottom of the cortex than expected
• fewer cells expressing neuronal marker BRN2 (deep layer neurons)are found at the top of the cortex than expected and more cells are found near the bottom of the cortex
|
