Phenotypes associated with this allele
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmnatm6Lgf mutation
(0 available);
any
Lmna mutation
(82 available)
|
|
|
cellular
|
• fibroblasts exhibit a higher frequency of nuclei blebs compared with cells from wild-type mice but less than in Lmnatm7Lgf homozygotes
• nuclear stiffness in fibroblasts is increased compared to cells from wild-type mice and Lmnatm7Lgf homozygotes
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmnatm6Lgf mutation
(0 available);
any
Lmna mutation
(82 available)
|
|
|
growth/size/body
|
• body weight of females are slightly but significantly lower than those of wild-type females
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmnatm6Lgf mutation
(0 available);
any
Lmna mutation
(82 available)
Zmpste24tm1Sgy mutation
(2 available);
any
Zmpste24 mutation
(32 available)
|
|
|
digestive/alimentary system
N |
• mice do not exhibit intestinal abnormalities
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmnatm6Lgf mutation
(0 available);
any
Lmna mutation
(82 available)
Zmpste24tm1Sgy mutation
(2 available);
any
Zmpste24 mutation
(32 available)
|
|
|
mortality/aging
|
• survival is worse than in Zmpste24 single mutants
|
|
• survival is worse than in Zmpste24 single mutants
|
growth/size/body
|
• smaller than Zmpste24 single mutants
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmnatm6Lgf mutation
(0 available);
any
Lmna mutation
(82 available)
Zmpste24tm1Sgy mutation
(2 available);
any
Zmpste24 mutation
(32 available)
|
|
|
mortality/aging
|
• survival is worse than in Zmpste24 single mutants
|
|
• survival is worse than in Zmpste24 single mutants
|
growth/size/body
|
• smaller than Zmpste24 single mutants
|