Mouse Genome Informatics
hm1
    Lmnatm5Lgf/Lmnatm5Lgf
involves: 129P2/OlaHsd * C57BL/6
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• median survival of males and females is 38.5 weeks and 49.5 weeks, respectively
• all male mice succumb by 44 weeks, and all female mice succumb by 80 weeks of age

cellular
• nuclei of fibroblasts were misshapen, with blebs and folds

growth/size
• body weight of females are slightly but significantly lower than those of wild-type females

cardiovascular system
• during systole
• phenotype is more severe in males
• significant fibrosis in the papillary muscle of the left ventricle, as judged by a Gomori trichrome stain
• fibrosis is typically mild to moderate
• with an increased left ventricular (LV) chamber size during systole and a reduced LV ejection fraction, with a greater severity in males
• decrease in left ventricular ejection fraction
• decrease is more severe in males

muscle
• with an increased left ventricular (LV) chamber size during systole and a reduced LV ejection fraction, with a greater severity in males
• decrease in left ventricular ejection fraction
• decrease is more severe in males

skeleton
N
• do not develop osteolytic lesions or spontaneous rib fractures (J:160705)

Mouse Models of Human Disease
OMIM IDRef(s)
NOT Hutchinson-Gilford Progeria Syndrome; HGPS 176670 J:160705