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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Lmnatm5Lgf
targeted mutation 5, Loren G Fong
MGI:4457607
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Lmnatm5Lgf/Lmnatm5Lgf involves: 129P2/OlaHsd * C57BL/6 MGI:4457609


Genotype
MGI:4457609
hm1
Allelic
Composition
Lmnatm5Lgf/Lmnatm5Lgf
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lmnatm5Lgf mutation (0 available); any Lmna mutation (61 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• median survival of males and females is 38.5 weeks and 49.5 weeks, respectively (J:160705)
• median survival of males and females is 38.5 weeks and 49.5 weeks, respectively (J:160705)
• all male mice succumb by 44 weeks, and all female mice succumb by 80 weeks of age (J:160705)
• all male mice succumb by 44 weeks, and all female mice succumb by 80 weeks of age (J:160705)

cellular
• nuclei of fibroblasts were misshapen, with blebs and folds (J:160705)
• nuclei of fibroblasts were misshapen, with blebs and folds (J:160705)

growth/size/body
• body weight of females are slightly but significantly lower than those of wild-type females (J:160705)
• body weight of females are slightly but significantly lower than those of wild-type females (J:160705)

cardiovascular system
• during systole (J:160705)
• phenotype is more severe in males (J:160705)
• during systole (J:160705)
• phenotype is more severe in males (J:160705)
• significant fibrosis in the papillary muscle of the left ventricle, as judged by a Gomori trichrome stain (J:160705)
• fibrosis is typically mild to moderate (J:160705)
• significant fibrosis in the papillary muscle of the left ventricle, as judged by a Gomori trichrome stain (J:160705)
• fibrosis is typically mild to moderate (J:160705)
• with an increased left ventricular (LV) chamber size during systole and a reduced LV ejection fraction, with a greater severity in males (J:160705)
• with an increased left ventricular (LV) chamber size during systole and a reduced LV ejection fraction, with a greater severity in males (J:160705)
• decrease in left ventricular ejection fraction (J:160705)
• decrease is more severe in males (J:160705)
• decrease in left ventricular ejection fraction (J:160705)
• decrease is more severe in males (J:160705)

muscle
• with an increased left ventricular (LV) chamber size during systole and a reduced LV ejection fraction, with a greater severity in males (J:160705)
• with an increased left ventricular (LV) chamber size during systole and a reduced LV ejection fraction, with a greater severity in males (J:160705)
• decrease in left ventricular ejection fraction (J:160705)
• decrease is more severe in males (J:160705)
• decrease in left ventricular ejection fraction (J:160705)
• decrease is more severe in males (J:160705)

skeleton
N
• do not develop osteolytic lesions or spontaneous rib fractures (J:160705)
• do not develop osteolytic lesions or spontaneous rib fractures (J:160705)

Mouse Models of Human Disease
OMIM ID Ref(s)
NOT Hutchinson-Gilford Progeria Syndrome; HGPS 176670 J:160705





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory