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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Mov10l1tm1.2Jw
targeted mutation 1.2, Jeremy Wang
MGI:4457276
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Mov10l1tm1.2Jw/Mov10l1tm1.2Jw involves: 129S4/SvJae * C57BL/6 * FVB/N MGI:4457286


Genotype
MGI:4457286
hm1
Allelic
Composition		 Mov10l1tm1.2Jw/Mov10l1tm1.2Jw
Genetic
Background		 involves: 129S4/SvJae * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mov10l1tm1.2Jw mutation (0 available); any Mov10l1 mutation (46 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:161125 )
N
• female mice exhibit normal fertility
azoospermia ( J:161125 )
• seminiferous tubules lack postmeiotic germ cells unlike in wild-type mice
abnormal DNA methylation during gametogenesis ( J:161125 )
• male germ cells exhibit demethylation and derepression of LINE1 and IAP retrotransposons unlike in wild-type cells
abnormal male meiosis ( J:161125 )
• synapsis fail to form unlike in wild-type cells
arrest of male meiosis ( J:161125 )
• early in meiosis
abnormal male reproductive system physiology ( J:161125 )
• prenatal gonocytes in testes exhibit derepression of LINE1 and IAP retrotransposons unlike in wild-type cells

cellular
azoospermia ( J:161125 )
• seminiferous tubules lack postmeiotic germ cells unlike in wild-type mice
abnormal DNA methylation during gametogenesis ( J:161125 )
• male germ cells exhibit demethylation and derepression of LINE1 and IAP retrotransposons unlike in wild-type cells

endocrine/exocrine glands




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory