Phenotypes associated with this allele

• Allele Symbol: Dusp5^{tm1a(KOMP)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4456654
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dusp5^tm1a(KOMP)Wtsi/Dusp5^tm1a(KOMP)Wtsi	C57BL/6-Dusp5^tm1a(KOMP)Wtsi	MGI:5906374

Genotype
MGI:5906374

hm1

• Allelic Composition: Dusp5^{tm1a(KOMP)Wtsi}/Dusp5^{tm1a(KOMP)Wtsi}
• Genetic Background: C57BL/6-Dusp5^{tm1a(KOMP)Wtsi}
• Cell Lines: EPD0575_3_B05

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal CD8-positive, alpha beta T cell morphology ( J:240637 )

• mice infected with LCMV exhibit decreased short-lived effector cells but increased memory precursor effector cells in the blood and spleen compared with wild-type mice

• however, populations are normal in the bone marrow or lymph nodes

increased effector memory CD8-positive, alpha-beta T cell number ( J:240637 )

• in mice infected with LCMV

abnormal T cell physiology ( J:240637 )

• cultured memory precursor effector (MPEC) T cells exhibit higher spare respiratory capacity and therefore increased mitochondrial function compared with wild-type cells

• however, metabolic stress response of cultured short-lived effector (SLEC) T cells is normal and glycolytic stress response is normal in SLEC and MPEC T cells

increased T cell apoptosis ( J:240637 )

• cultured short-lived effector and memory precursor effector T cells exhibit increased necrotic cells with reduced live cells compared with wild-type mice

• however, no changes are observed after T cell receptor activation or after 1 day of interleukin stimulation

increased T cell proliferation ( J:240637 )

• day 4 cultured short-lived effector and memory precursor effector T cells exhibit decreased fraction of cells in G1 and G2 phase and increase in cells in S phase compared with wild-type mice

• however, proliferation is normal at day 6 in culture

cellular

increased T cell apoptosis ( J:240637 )

• cultured short-lived effector and memory precursor effector T cells exhibit increased necrotic cells with reduced live cells compared with wild-type mice

• however, no changes are observed after T cell receptor activation or after 1 day of interleukin stimulation

increased T cell proliferation ( J:240637 )

• day 4 cultured short-lived effector and memory precursor effector T cells exhibit decreased fraction of cells in G1 and G2 phase and increase in cells in S phase compared with wild-type mice

• however, proliferation is normal at day 6 in culture

hematopoietic system

abnormal bone marrow cell morphology/development ( J:240637 )

• bone marrow transfer experiments confirmed that the defect in T cell development is cell intrinsic

abnormal CD8-positive, alpha beta T cell morphology ( J:240637 )

• mice infected with LCMV exhibit decreased short-lived effector cells but increased memory precursor effector cells in the blood and spleen compared with wild-type mice

• however, populations are normal in the bone marrow or lymph nodes

increased effector memory CD8-positive, alpha-beta T cell number ( J:240637 )

• in mice infected with LCMV

abnormal T cell physiology ( J:240637 )

• cultured memory precursor effector (MPEC) T cells exhibit higher spare respiratory capacity and therefore increased mitochondrial function compared with wild-type cells

• however, metabolic stress response of cultured short-lived effector (SLEC) T cells is normal and glycolytic stress response is normal in SLEC and MPEC T cells

increased T cell apoptosis ( J:240637 )

• cultured short-lived effector and memory precursor effector T cells exhibit increased necrotic cells with reduced live cells compared with wild-type mice

• however, no changes are observed after T cell receptor activation or after 1 day of interleukin stimulation

increased T cell proliferation ( J:240637 )

• day 4 cultured short-lived effector and memory precursor effector T cells exhibit decreased fraction of cells in G1 and G2 phase and increase in cells in S phase compared with wild-type mice

• however, proliferation is normal at day 6 in culture