Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp11cambr mutation
(2 available);
any
Atp11c mutation
(16 available)
Tg(IghelMD4)4Ccg mutation
(3 available)
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hematopoietic system
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• immature B cell numbers are partially rescued compared to in Atp11cambr hemizygotes
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• pro-B cell numbers are partially rescued compared to in Tg(IghelMD4)4Ccg mice
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immune system
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• immature B cell numbers are partially rescued compared to in Atp11cambr hemizygotes
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• pro-B cell numbers are partially rescued compared to in Tg(IghelMD4)4Ccg mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp11cambr mutation
(2 available);
any
Atp11c mutation
(16 available)
Tg(H2-Ea-Il7)10Rhdr mutation
(1 available)
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hematopoietic system
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• mice exhibit a limited rescue of B cell numbers compared to in Atp11cambr hemizygotes
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immune system
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• mice exhibit a limited rescue of B cell numbers compared to in Atp11cambr hemizygotes
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp11cambr mutation
(2 available);
any
Atp11c mutation
(16 available)
Tg(Vav-BCL2)69Jad mutation
(4 available)
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immune system
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• mice exhibit a limited rescue of B cell numbers compared to in Atp11cambr hemizygotes
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• the number of immature B cells is partially recovered compared to in Atp11cambr hemizygotes
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• the number of pre-B cells is partially recovered compared to in Atp11cambr hemizygotes
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hematopoietic system
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• mice exhibit a limited rescue of B cell numbers compared to in Atp11cambr hemizygotes
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• the number of immature B cells is partially recovered compared to in Atp11cambr hemizygotes
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• the number of pre-B cells is partially recovered compared to in Atp11cambr hemizygotes
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp11cambr mutation
(2 available);
any
Atp11c mutation
(16 available)
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immune system
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• B cell differentiation from pro-B cells into pre-B and immature cells is disrupted compared to in wild-type mice
• mice exhibit less transition of pro-B cells from immunoglobulin- to immunoglobulin+ cells compared with wild-type mice
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• mice exhibit decreased B cell frequency in the blood, peritoneal cavity, and spleen compared with wild-type mice
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• in the bone marrow and spleen
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• in the peritoneal cavity
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• in the peritoneal cavity
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• in the peritoneal cavity
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• in the peritoneal cavity
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• mice treated with inactivated Bordetella pertussis or alum-precipitated chicken gamma-globulin (CGG) coupled to the hapten azo-benzene-arsonate (ABA) exhibit reduced antibody response compared with wild-type mice
• booster immunization with ABA-CGG failed to produce anti-ABA antibodies unlike in wild-type mice
• however, antibody response to NP-Ficoll is normal
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neoplasm
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• in all months at 6 months of age with areas of hemorrhage, necrosis, and hypervascularity
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homeostasis/metabolism
hematopoietic system
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N |
• mice exhibit normal numbers of major blood cell progenitors and lineages in the bone marrow
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• B cell differentiation from pro-B cells into pre-B and immature cells is disrupted compared to in wild-type mice
• mice exhibit less transition of pro-B cells from immunoglobulin- to immunoglobulin+ cells compared with wild-type mice
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• mice exhibit decreased B cell frequency in the blood, peritoneal cavity, and spleen compared with wild-type mice
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• in the bone marrow and spleen
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• in the peritoneal cavity
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• in the peritoneal cavity
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• in the peritoneal cavity
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• in the peritoneal cavity
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liver/biliary system
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• in all months at 6 months of age with areas of hemorrhage, necrosis, and hypervascularity
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Analysis Tools