Phenotypes associated with this allele

• Allele Symbol: Kcne3^tm1.1Tjj
• Allele Name: targeted mutation 1.1, Thomas J Jentsch
• Allele ID: MGI:4456241
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kcne3^tm1.1Tjj/Kcne3^tm1.1Tjj	involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J	MGI:4456245

Genotype
MGI:4456245

hm1

• Allelic Composition: Kcne3^tm1.1Tjj/Kcne3^tm1.1Tjj
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

abnormal digestive system physiology ( J:160721 )

• the cAMP-stimulated, C293B-sensitive current component in tracheal epithelium is almost absent compared to in wild-type cells

abnormal intestine physiology ( J:160721 )

• colon epithelia almost lack forskolin-stimulated currents compared with wild-type cells

• mean differential currents in the distal colon, jejunum, and ileum treated with amiloride and forskolin are reduced compared with similarly treated wild-type cells

respiratory system

abnormal respiratory system physiology ( J:160721 )

• the response to forskolin/IBMX in tracheal epithelia is drastically reduced compared to in wild-type cells

• maximal and steady state differential short circuit currents induced by ATP are reduced in tracheal epithelia compared to in wild-type cells

• mean differential currents induced by ATP, forskolin/IBMX, or carbachol in tracheal epithelial cells are lower than in similarly treated wild-type cells

homeostasis/metabolism

abnormal physiological response to xenobiotic ( J:160721 )

• the cAMP-stimulated, C293B-sensitive current component in tracheal epithelium is almost absent compared to in wild-type cells

• colon epithelia almost lack forskolin-stimulated currents compared with wild-type cells

• mean differential currents in the distal colon, jejunum, and ileum treated with amiloride and forskolin are reduced compared with similarly treated wild-type cells

• the response to forskolin/IBMX in tracheal epithelia is drastically reduced compared to in wild-type cells

• mean differential currents induced by ATP, forskolin/IBMX, or carbachol in tracheal epithelial cells are lower than in similarly treated wild-type cells

• maximal and steady state differential short circuit currents induced by ATP are reduced in tracheal epithelia compared to in wild-type cells