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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Kcne3tm1.1Tjj
targeted mutation 1.1, Thomas J Jentsch
MGI:4456241
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Kcne3tm1.1Tjj/Kcne3tm1.1Tjj involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J MGI:4456245


Genotype
MGI:4456245
hm1
Allelic
Composition
Kcne3tm1.1Tjj/Kcne3tm1.1Tjj
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * BALB/cJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kcne3tm1.1Tjj mutation (0 available); any Kcne3 mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• the cAMP-stimulated, C293B-sensitive current component in tracheal epithelium is almost absent compared to in wild-type cells
• colon epithelia almost lack forskolin-stimulated currents compared with wild-type cells
• mean differential currents in the distal colon, jejunum, and ileum treated with amiloride and forskolin are reduced compared with similarly treated wild-type cells

respiratory system
• the response to forskolin/IBMX in tracheal epithelia is drastically reduced compared to in wild-type cells
• maximal and steady state differential short circuit currents induced by ATP are reduced in tracheal epithelia compared to in wild-type cells
• mean differential currents induced by ATP, forskolin/IBMX, or carbachol in tracheal epithelial cells are lower than in similarly treated wild-type cells

homeostasis/metabolism
• the cAMP-stimulated, C293B-sensitive current component in tracheal epithelium is almost absent compared to in wild-type cells
• colon epithelia almost lack forskolin-stimulated currents compared with wild-type cells
• mean differential currents in the distal colon, jejunum, and ileum treated with amiloride and forskolin are reduced compared with similarly treated wild-type cells
• the response to forskolin/IBMX in tracheal epithelia is drastically reduced compared to in wild-type cells
• mean differential currents induced by ATP, forskolin/IBMX, or carbachol in tracheal epithelial cells are lower than in similarly treated wild-type cells
• maximal and steady state differential short circuit currents induced by ATP are reduced in tracheal epithelia compared to in wild-type cells





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
04/06/2021
MGI 6.16
The Jackson Laboratory