All Phenotypes Rr94<tm3.2Litt> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rr94^tm3.2Litt/Rr94^tm3.2Litt	involves: 129P2/OlaHsd * FVB/N	MGI:4452090
cx2	Rr94^tm3.2Litt/Rr94^tm3.2Litt H2-Ab1^b-tm1Gru/H2-Ab1^b-tm1Gru	involves: 129P2/OlaHsd * 129S2/SvPas * FVB/N	MGI:4452092
cx3	B2m^tm1Jae/B2m^tm1Jae Rr94^tm3.2Litt/Rr94^tm3.2Litt	involves: 129P2/OlaHsd * 129S2/SvPas * FVB/N	MGI:4452093
cx4	Rr94^tm3.2Litt/Rr94⁺ Rr112^tm4.1Litt/Rr112⁺	involves: 129P2/OlaHsd * 129S4/SvJaeSor * FVB/N	MGI:4452096

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:158962 )

N	• the total cell numbers in the thymus and peripheral lymphoid organs are normal

abnormal T cell differentiation ( J:158962 )

• the proportion of CD4- T cells increased following TCR activation unlike in wild-type mice

abnormal double-positive T cell morphology ( J:158962 )

• CD4 expression is absent in preseletion double positive thymocytes unlike wild-type mice

• however, CD4 expression is present in post-positive selection thymocytes and maintained in CD4 single positive mature thymocytes and the frequency of positively selected TCRbeta^hiCD24hi69+ or TCRbeta^hiCD24^lo69- thymocytes, or of TCRbeta+ splenocytes is normal

decreased double-positive T cell number ( J:158962 )

• the double positive population in the thymus is lost unlike in wild-type mice

abnormal T cell subpopulation ratio ( J:158962 )

• the ratio of CD4 single positive to CD8 single positive T cells is inverted compared to in wild-type mice

increased CD8-positive, alpha-beta T cell number ( J:158962 )

• in the thymus

abnormal CD4-positive, alpha beta T cell morphology ( J:158962 )

• CD4 expression level in mature CD4+ cells is one third of expression in CD4+ T cells from wild-type mice

• CD4^lo T cells lose CD4 expression within 2 divisions following TCR activation unlike wild-type cells

decreased CD4-positive, alpha-beta T cell number ( J:158962 )

• the percentage of CD4 single positive cell in the thymus is decreased compared to in wild-type mice

• the number of TCRbeta+ CD4+ T cells in the spleen is decreased compared to in wild-type mice

hematopoietic system

abnormal T cell differentiation ( J:158962 )

• the proportion of CD4- T cells increased following TCR activation unlike in wild-type mice

abnormal double-positive T cell morphology ( J:158962 )

• CD4 expression is absent in preseletion double positive thymocytes unlike wild-type mice

decreased double-positive T cell number ( J:158962 )

• the double positive population in the thymus is lost unlike in wild-type mice

abnormal T cell subpopulation ratio ( J:158962 )

• the ratio of CD4 single positive to CD8 single positive T cells is inverted compared to in wild-type mice

increased CD8-positive, alpha-beta T cell number ( J:158962 )

• in the thymus

abnormal CD4-positive, alpha beta T cell morphology ( J:158962 )

• CD4 expression level in mature CD4+ cells is one third of expression in CD4+ T cells from wild-type mice

• CD4^lo T cells lose CD4 expression within 2 divisions following TCR activation unlike wild-type cells

decreased CD4-positive, alpha-beta T cell number ( J:158962 )

• the percentage of CD4 single positive cell in the thymus is decreased compared to in wild-type mice

• the number of TCRbeta+ CD4+ T cells in the spleen is decreased compared to in wild-type mice

Allelic Composition	Rr94^tm3.2Litt/Rr94^tm3.2Litt H2-Ab1^b-tm1Gru/H2-Ab1^b-tm1Gru
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
H2-Ab1^b-tm1Gru mutation (11 available); any H2-Ab1 mutation (81 available)
Rr94^tm3.2Litt mutation (0 available); any Rr94 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:158962 )

N	• the expression of CD4 in post-selection thymocytes is normal

abnormal T cell subpopulation ratio ( J:158962 )

• the ratio of CD4 single positive to CD8 single positive T cells is inverted compared to in wild-type mice

decreased CD4-positive, alpha-beta T cell number ( J:158962 )

• mature CD4 single positive and peripheral CD4^lo T cell populations are largely lost unlike in wild-type mice

increased CD8-positive, alpha-beta T cell number ( J:158962 )

• in the thymus

hematopoietic system

abnormal T cell subpopulation ratio ( J:158962 )

• the ratio of CD4 single positive to CD8 single positive T cells is inverted compared to in wild-type mice

decreased CD4-positive, alpha-beta T cell number ( J:158962 )

• mature CD4 single positive and peripheral CD4^lo T cell populations are largely lost unlike in wild-type mice

increased CD8-positive, alpha-beta T cell number ( J:158962 )

• in the thymus

Allelic Composition	B2m^tm1Jae/B2m^tm1Jae Rr94^tm3.2Litt/Rr94^tm3.2Litt
Genetic Background	involves: 129P2/OlaHsd * 129S2/SvPas * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2m^tm1Jae mutation (8 available); any B2m mutation (122 available)
Rr94^tm3.2Litt mutation (0 available); any Rr94 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased T cell proliferation ( J:158962 )

• thymocytes exhibit lymphopenia-induced homeostatic proliferation in the periphery unlike in wild-type mice

abnormal T cell differentiation ( J:158962 )

• the frequency of TCRbeta^hi thymocyte is decreased 10-fold compared to in wild-type mice

• mice exhibit peripheral TCRbeta<+> T cells that do not express CD4 or CD8 unlike in wild-type mice

• mice exhibit a reduction in mature thymocyte output compared with wild-type mice

• however, the expression of CD4 in post-selection thymocytes is normal

abnormal T cell subpopulation ratio ( J:158962 )

• the ratio of CD4 single positive to CD8 single positive T cells is inverted compared to in wild-type mice

decreased CD4-positive, alpha-beta T cell number ( J:158962 )

• in the thymus

increased CD8-positive, alpha-beta T cell number ( J:158962 )

• in the thymus

hematopoietic system

increased T cell proliferation ( J:158962 )

• thymocytes exhibit lymphopenia-induced homeostatic proliferation in the periphery unlike in wild-type mice

abnormal T cell differentiation ( J:158962 )

• the frequency of TCRbeta^hi thymocyte is decreased 10-fold compared to in wild-type mice

• mice exhibit peripheral TCRbeta<+> T cells that do not express CD4 or CD8 unlike in wild-type mice

• mice exhibit a reduction in mature thymocyte output compared with wild-type mice

• however, the expression of CD4 in post-selection thymocytes is normal

abnormal T cell subpopulation ratio ( J:158962 )

• the ratio of CD4 single positive to CD8 single positive T cells is inverted compared to in wild-type mice

decreased CD4-positive, alpha-beta T cell number ( J:158962 )

• in the thymus

increased CD8-positive, alpha-beta T cell number ( J:158962 )

• in the thymus

cellular

increased T cell proliferation ( J:158962 )

• thymocytes exhibit lymphopenia-induced homeostatic proliferation in the periphery unlike in wild-type mice

Allelic Composition	Rr94^tm3.2Litt/Rr94⁺ Rr112^tm4.1Litt/Rr112⁺
Genetic Background	involves: 129P2/OlaHsd * 129S4/SvJaeSor * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T cell differentiation ( J:158962 )

• mice exhibit the same phenotype as Cd4^tm3.2Litt homozygotes

abnormal T cell subpopulation ratio ( J:158962 )

• the ratio of CD4 single positive to CD8 single positive T cells is inverted compared to in wild-type mice

decreased CD4-positive, alpha-beta T cell number ( J:158962 )

• mice exhibit a decreased in CD4 expression in lamina propria lin-c-kit+CD127+ cells compared to in wild-type mice

increased CD8-positive, alpha-beta T cell number ( J:158962 )

• in the thymus and spleen

hematopoietic system

abnormal T cell differentiation ( J:158962 )

• mice exhibit the same phenotype as Cd4^tm3.2Litt homozygotes

abnormal T cell subpopulation ratio ( J:158962 )

• the ratio of CD4 single positive to CD8 single positive T cells is inverted compared to in wild-type mice

decreased CD4-positive, alpha-beta T cell number ( J:158962 )

• mice exhibit a decreased in CD4 expression in lamina propria lin-c-kit+CD127+ cells compared to in wild-type mice

increased CD8-positive, alpha-beta T cell number ( J:158962 )

• in the thymus and spleen

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