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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Slc13a4tm1a(EUCOMM)Wtsi
targeted mutation 1a, Wellcome Trust Sanger Institute
MGI:4441655
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Slc13a4tm1a(EUCOMM)Wtsi/Slc13a4tm1a(EUCOMM)Wtsi involves: C57BL/6J * C57BL/6N MGI:5896624
ht2
Slc13a4tm1a(EUCOMM)Wtsi/Slc13a4+ involves: C57BL/6J * C57BL/6N MGI:5896625


Genotype
MGI:5896624
hm1
Allelic
Composition
Slc13a4tm1a(EUCOMM)Wtsi/Slc13a4tm1a(EUCOMM)Wtsi
Genetic
Background
involves: C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc13a4tm1a(EUCOMM)Wtsi mutation (0 available); any Slc13a4 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• gross abnormalities are seen at E12.5 and all are dead by E18.5

embryo
• impaired placental sulfate transfer at E12.5
• however, placental morphology is similar to controls

homeostasis/metabolism
• at E16.5
• embryos display a ~50% reduction in elemental sulfur

skeleton
• skeletal defects
• complete loss of ossification in the fetus at E16.5

craniofacial
• craniofacial malformations are seen at E16.5
• failure of elevation and fusion
• at E14.5

vision/eye
• thickened at E14.5
• iris and lens coloboma at E14.5

cardiovascular system
• disrupted with reduced complexity at E14.5
• vascular hemorrhaging

integument
• at E16.5
• at E16.5

growth/size/body
• failure of elevation and fusion
• at E14.5

digestive/alimentary system
• failure of elevation and fusion
• at E14.5




Genotype
MGI:5896625
ht2
Allelic
Composition
Slc13a4tm1a(EUCOMM)Wtsi/Slc13a4+
Genetic
Background
involves: C57BL/6J * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc13a4tm1a(EUCOMM)Wtsi mutation (0 available); any Slc13a4 mutation (18 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• disorganized rib cage at E16.5
• decreased calcification at E16.5 in areas of the axial skeleton and skull





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
06/30/2020
MGI 6.15
The Jackson Laboratory