All Phenotypes Dnajc6<tm1Legr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Dnajc6^tm1Legr
targeted mutation 1, Lois Greene
MGI:4440489

Summary

2 genotypes

Allelic Composition	Dnajc6^tm1Legr/Dnajc6^tm1Legr
Genetic Background	B6.129-Dnajc6^tm1Legr

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dnajc6^tm1Legr mutation (1 available); any Dnajc6 mutation (59 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Accumulation of clathrin-coated vesicles and clathrin cages at Dnajc6^tm1Legr/Dnajc6^tm1Legr synapses from deep cerebellar nuclei

mortality/aging

• although present in Mendelian ratios at birth, fewer than expected mice are alive at weaning

reproductive system

delayed female fertility ( J:158574 )

nervous system

abnormal synaptic vesicle number ( J:158574 )

• more clatherin-coated vesicles and clatherin cages are found in nerve terminals compared to in wild-type mice

• however, the total number of synaptic vesicles is normal

• the rate of vesicle endocytosis at hippocampal synapses is decreased compared to in wild-type mice

growth/size/body

decreased birth weight ( J:158574 )

decreased body weight ( J:158574 )

• at 1 week of age, mice are 40% lighter than wild-type mice

Allelic Composition	Dnajc6^tm1Legr/Dnajc6⁺
Genetic Background	B6.129-Dnajc6^tm1Legr